Antihyperglycemic and Antihyperlipidemic Effects of Ferula duranii in Experimental Type 2 Diabetic Rats

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dc.contributor.authorYusufoglu, Hasan S.
dc.contributor.authorSoliman, Gamal A.
dc.contributor.authorAbdel-Rahman, Rehab F.
dc.contributor.authorAbdel-Kader, Maged Saad
dc.contributor.authorGanaie, Majid A.
dc.contributor.authorBedir, Erdal
dc.contributor.authorBaykan, Sura
dc.contributor.authorOzturk, Bintug
dc.date.accessioned2019-10-27T22:28:59Z
dc.date.available2019-10-27T22:28:59Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractIn the present study, DPPH radical scavenging assay and ferric-reducing antioxidant assay were used to evaluate in vitro antioxidant potential of the methanol extract of Ferula duranii (F. duranii). The antihyperglycemic and antihyperlipidemic activities of F. duranii extract were evaluated in streptozotocin (STZ)-induced diabetic rats. F. duranii showed considerable antioxidant potential in the DPPH radical scavenging assay and minimum reducing power in ferric-reducing antioxidant power assay. A meaningful reduction in the concentrations of Fasting Blood Glucose (FBG), glycosylated hemoglobin (Hb Alc), triglycerides (TG), Total Cholesterol (TC) and Low Density Lipoprotein (LDL-C) in plasma and an elevation in the activity of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) in hepatic and pancreas homogenates were observed in diabetic animals medicated with F. duranii extract in comparison with diabetic control rats. The level of insulin raised significantly in plasma of diabetic groups received F. duranii in respect to diabetic control one. Levels of alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), bilirubin, total protein and High Density Lipoprotein (HDL-C) in plasma and malondialdehyde (MDA) in liver and pancreas homogenates were recovered significantly in F. duranii-medicated diabetic rats in comparison with diabetic controls. The present data suggest that F. duranii has both antidiabetic and antihyperlipidemic effects.en_US
dc.description.sponsorshipDeanship of Scientific Research, Prince Sattam Bin Abdulaziz University, Al-Kharj, KSA [2014/01/787]en_US
dc.description.sponsorshipThis project was supported by Support Research Projects with Global Partnership Program, Deanship of Scientific Research, Prince Sattam Bin Abdulaziz University, Al-Kharj, KSA. Grant No. 2014/01/787. The authors would like to express their gratitude to the Deanship of Scientific Research at Prince Sattam bin Abdulaziz University Al-Kharj, for their assistance.en_US
dc.identifier.doi10.3923/ijp.2015.532.541
dc.identifier.endpage541en_US
dc.identifier.issn1811-7775
dc.identifier.issn1812-5700
dc.identifier.issn1811-7775en_US
dc.identifier.issn1812-5700en_US
dc.identifier.issue6en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage532en_US
dc.identifier.urihttps://doi.org/10.3923/ijp.2015.532.541
dc.identifier.urihttps://hdl.handle.net/11454/51021
dc.identifier.volume11en_US
dc.identifier.wosWOS:000369214000002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherAsian Network Scientific Information-Ansineten_US
dc.relation.ispartofInternational Journal of Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFerula duraniien_US
dc.subjectdiabetesen_US
dc.subjectstreptozotocinen_US
dc.subjecthypolipidemicen_US
dc.subjectratsen_US
dc.titleAntihyperglycemic and Antihyperlipidemic Effects of Ferula duranii in Experimental Type 2 Diabetic Ratsen_US
dc.typeArticleen_US

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