In vitro release kinetics of polycaprolactone encapsulated plant extract fabricated by supercritical antisolvent process and solvent evaporation method

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dc.contributor.authorYesil-Celiktas, Ozlem
dc.contributor.authorCetin-Uyanikgil, Emel Oyku
dc.date.accessioned2019-10-27T21:44:33Z
dc.date.available2019-10-27T21:44:33Z
dc.date.issued2012
dc.departmentEge Üniversitesien_US
dc.description.abstractPolymer microspheres are becoming attractive drug delivery systems due to their biodegradability, non-toxicity and easy administration. In this study, a rosemary extract exhibiting anti-proliferative activity against various human cancer cell lines was encapsulated by polycaprolactone using gas anti-solvent process and solvent evaporation method. The particles were characterized by X-ray diffraction, differential scanning calorimeters analyses and scanning electron microscopy, whereas in vitro release kinetics was determined by the dialysis cell method. Although the fabrication methods seemed not to play an important role in the diffusion rate and release profiles of both loaded samples in aqueous medium, fabricated rosemary extract with gas antisolvent process at 300 bar, 40 degrees C and a flow rate of 20 g/min exhibited a narrow particle size distribution, a lower mean particle size and higher encapsulation efficiency (254.5 nm, 82.8%) compared to the traditional fabrication method (617.5 nm, 62.2%). (c) 2011 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.supflu.2011.11.005
dc.identifier.endpage225en_US
dc.identifier.issn0896-8446
dc.identifier.issn0896-8446en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage219en_US
dc.identifier.urihttps://doi.org/10.1016/j.supflu.2011.11.005
dc.identifier.urihttps://hdl.handle.net/11454/47262
dc.identifier.volume62en_US
dc.identifier.wosWOS:000301327100027en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofJournal of Supercritical Fluidsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSupercritical antisolventen_US
dc.subjectEncapsulationen_US
dc.subjectNanoparticleen_US
dc.subjectRosemaryen_US
dc.subjectAnti-canceren_US
dc.subjectPolycaprolactoneen_US
dc.subjectIn vitro release kineticsen_US
dc.titleIn vitro release kinetics of polycaprolactone encapsulated plant extract fabricated by supercritical antisolvent process and solvent evaporation methoden_US
dc.typeArticleen_US

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