Fig seed oil improves intestinal damage caused by 5-FU-induced mucositis in rats

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dc.contributor.authorAlan, Nurten
dc.contributor.authorOran, Nazan Tuna
dc.contributor.authorYilmaz, Pinar Akokay
dc.contributor.authorCelik, Asli
dc.contributor.authorYilmaz, Osman
dc.date.accessioned2024-08-31T07:47:38Z
dc.date.available2024-08-31T07:47:38Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractIntestinal mucositis poses a significant concern associated with cancer therapy. This study aims to investigate the protective and/or healing effect of fig seed oil (FSO) on 5-fluorouracil (5-FU)-induced intestinal mucositis by targeting inflammatory markers and histologic changes in rats. Albino Wistar adult rats were randomly divided into four groups, including three male and three female animals. All the animals in the four groups had a normal standard diet and water throughout the experimental period, which lasted up to 11 days. Rats were administered FSO 0.6 mL (mucositis FSO group) and FSO 0.2 mL (mucositis FSO-R group) daily throughout the experiment. These two groups and one additional group (mucositis group) were given an intraperitoneal injection of 5-FU (300 mg/kg) on Day 5 of the experiment. In contrast, the fourth group (Control group) was given an intraperitoneal saline injection on Day 5 of the experiment. FSO treatment ameliorated 5-FU-induced intestinal mucositis. On immunohistologic examination, FSO suppressed significantly the activation of NF-kappa B and expression of IL-beta and TNF-alpha of the harvested intestinal tissue. The reduced dose FSO (mucositis FSO-R) was as effective as the full dose (mucositis FSO) in suppressing IL-beta and TNF-alpha production, but was not as effective as the full dose in suppressing NF-kappa B. On light microscopy, FSO attenuated significantly 5-FU-induced anomalies, such as the reduction of intestinal villus length and Goblet cell count. The reduced dose FSO (mucositis FSO-R) was as effective as the full dose (mucositis FSO) in restoring villus length, but was not as effective as the full dose in restoring Goblet cell count. The findings of the study suggest that FSO inhibits 5-FU-induced intestinal mucositis via modulation of mucosal inflammation.en_US
dc.description.sponsorshipScientific Research Project Office of Dokuz Eyll University; Planning and Monitoring Coordination of Organizational Development; Directorate of Library and Documentation at Ege Universityen_US
dc.description.sponsorshipWe extend our gratitude to the Planning and Monitoring Coordination of Organizational Development and the Directorate of Library and Documentation at Ege University for their invaluable assistance in editing and proofreading this study.en_US
dc.identifier.doi10.1002/fsn3.4283
dc.identifier.issn2048-7177
dc.identifier.scopus2-s2.0-85196301505en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1002/fsn3.4283
dc.identifier.urihttps://hdl.handle.net/11454/104499
dc.identifier.wosWOS:001250005600001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofFood Science & Nutritionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240831_Uen_US
dc.subjectChemotherapyen_US
dc.subjectFig Seed Oilen_US
dc.subjectFluorouracilen_US
dc.subjectMucositisen_US
dc.titleFig seed oil improves intestinal damage caused by 5-FU-induced mucositis in ratsen_US
dc.typeArticleen_US

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