The Use of Mean Platelet Volume, Plateletcrit, and N-terminal Brain Natriuretic Peptide as Biomarkers of Coronary Artery Involvement in Atypical Kawasaki Disease

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dc.contributor.authorDogan, Eser
dc.contributor.authorTuran, Caner
dc.contributor.authorYurtseven, Ali
dc.contributor.authorEman, Gamze
dc.contributor.authorSaz, Eylem Ulas
dc.date.accessioned2024-08-25T18:53:18Z
dc.date.available2024-08-25T18:53:18Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: Coronary artery aneurysm and ectasia develop in approximately 15% to 25% of children with untreated Kawasaki disease (KD). Atypical KD has a higher incidence of coronary artery involvement compared to typical KD. Our aim in this study was to identify new markers to support early diagnosis and prevent complications associated with delayed treatment in atypical KD. Method: The patients' demographic characteristics, presenting complaints, clinical findings, mean platelet volume (MPV), plateletcrit (PCT), and N-terminal brain natriuretic peptide (NT-proBNP) levels were analyzed. Coronary artery abnormalities were evaluated using two-dimensional echocardiography. Results are expressed as mean (+/- standard deviation). Results: Sixty children between the ages of 3 and 96 months who were diagnosed with atypical KD were included. Forty consecutive normal children were included as a control group. NT-proBNP, MPV, and PCT values were 381.7 (+/- 272.7 ) pg/mL, 5.8 (+/- 0.93 ) fL, and 0.266% (+/- 0.9 2%) in the patient group and 48.5 (+/- 28.5 ) pg/mL, 8.29 (+/- 1.12 ) fL, and 0.227% (+/- 0.7 8%) in the control group, respectively (p<0.00 1 for all). In the comparison of atypical KD patients with coronary artery involvement (CAI subgroup) and without (non-CAI subgroup), the NT-proBNP values in these subgroups were 542.9 (+/- 226.8 ) and 171 (+/- 161.7 ) pg/mL (p<0.001), MPV values were 5.8 (+/- 0.77 ) and 6.54 (+/- 0.95 ) fL (p<0.005), and PCT values were 0.264% (+/- 0. 1%) and 0.269% (+/- 0.0 8%), respectively. Conclusion: The simultaneous evaluation of MPV, PCT, and NT-proBNP was useful for the diagnosis of atypical KD. NT-proBNP and MPV can be used as markers of CAI in atypical KD.en_US
dc.identifier.doi10.4274/buchd.galenos.2022.75002
dc.identifier.endpage36en_US
dc.identifier.issn2822-4469
dc.identifier.issue1en_US
dc.identifier.startpage30en_US
dc.identifier.urihttps://doi.org/10.4274/buchd.galenos.2022.75002
dc.identifier.urihttps://hdl.handle.net/11454/103014
dc.identifier.volume13en_US
dc.identifier.wosWOS:000961981800005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofJournal of Dr Behcet Uz Childrens Hospitalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240825_Gen_US
dc.subjectKawasaki diseaseen_US
dc.subjectmean platelet volumeen_US
dc.subjectplateletcriten_US
dc.subjectn-terminal brain natriuretic peptideen_US
dc.subjectDiagnosisen_US
dc.subjectChildrenen_US
dc.subjectAneurysmsen_US
dc.subjectLesionsen_US
dc.titleThe Use of Mean Platelet Volume, Plateletcrit, and N-terminal Brain Natriuretic Peptide as Biomarkers of Coronary Artery Involvement in Atypical Kawasaki Diseaseen_US
dc.typeArticleen_US

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