18FDG conjugated magnetic nanoparticle probes: Synthesis and in vitro investigations on MCF-7 breast cancer cells

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dc.contributor.authorOzkaya F.
dc.contributor.authorUnak P.
dc.contributor.authorMedine E.I.
dc.contributor.authorSakarya S.
dc.contributor.authorUnak G.
dc.contributor.authorTimur S.
dc.date.accessioned2019-10-27T08:23:55Z
dc.date.available2019-10-27T08:23:55Z
dc.date.issued2013
dc.departmentEge Üniversitesien_US
dc.description.abstract18FDG conjugated magnetic iron oxide nanoparticles (MNPs) were synthesized as PET-MR hybrid imaging agent. Synthesized and characterized NPs were then applied to MCF-7 human breast cancer cells. 18FDG conjugated MNPs exhibited the cell incorporation ratio up to 30 %. As well as the characterization studies, apoptotic effects were observed depending on the cellular incorporations by the time. In conclusion, synthesized structures could have a potential as hybrid imaging agent in PET-MR imaging systems besides apoptotic effect on cancer cells. © 2012 Akadémiai Kiadó, Budapest, Hungary.en_US
dc.description.sponsorshipCentral University Basic Scientific Research Business Expenses Special Funds Ege Üniversitesien_US
dc.description.sponsorshipAcknowledgments The authors thank to Ege University Scientific Research Fund for the financial support with the Project Numbers 2008 NBE 08 and 2009 FEN 007. Authors also thank to Adnan Menderes University Science Technology Research and Application Center for cell culture experiments. --en_US
dc.identifier.doi10.1007/s10967-012-2248-2
dc.identifier.endpage1796en_US
dc.identifier.issn0236-5731
dc.identifier.issn0236-5731en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1789en_US
dc.identifier.urihttps://doi.org/10.1007/s10967-012-2248-2
dc.identifier.urihttps://hdl.handle.net/11454/26503
dc.identifier.volume295en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Radioanalytical and Nuclear Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject18Fen_US
dc.subjectApoptosisen_US
dc.subjectCancer diagnosisen_US
dc.subjectMagnetite nanoparticlesen_US
dc.subjectMannose triflateen_US
dc.title18FDG conjugated magnetic nanoparticle probes: Synthesis and in vitro investigations on MCF-7 breast cancer cellsen_US
dc.typeArticleen_US

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