Investigation of the bactericidal effects of vancomycin and quinupristin/dalfopristin on Staphylococcus aureus isolates

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dc.contributor.authorHoşgör-Limoncu M.
dc.contributor.authorErmertcan Ş.
dc.contributor.authorCoşar G.
dc.date.accessioned2019-10-27T00:22:28Z
dc.date.available2019-10-27T00:22:28Z
dc.date.issued2004
dc.departmentEge Üniversitesien_US
dc.description.abstractThe present study aimed to determine the correlation between the bactericidal activity of vancomycin and quinupristin/dalfopristin (Q/D) on Staphylococcus aureus isolates and their minimal inhibition concentrations. The in-vitro susceptibilities of the 99 S. aureus isolates to vancomycin and Q/D were investigated by agar dilution. Thirty methicillin-resistant S. aureus (MRSA) and 30 methicillin-susceptible S. aureus (MSSA) vancomycin and Q/D susceptible isolates were involved in time-kill studies. While both MRSA and MSSA isolates were susceptible to vancomycin, 96% of both isolates were determined as susceptible to Q/D. In the time-kill test, after 6 h of incubation vancomycin exhibited a bactericidal activity of 90% on MRSA and 100% on MSSA isolates. On the other hand, in the same incubation period Q/D was 47% and 93% bactericidal for MRSA and MSSA isolates, respectively. After 24 h of incubation, while vancomycin was bactericidal for all MRSA and MSSA isolates, Q/D exhibited a bactericidal activity of 93% on MRSA isolates and 97% on MSSA isolates.en_US
dc.identifier.endpage119en_US
dc.identifier.issn1300-0144
dc.identifier.issn1300-0144en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage115en_US
dc.identifier.urihttps://hdl.handle.net/11454/22602
dc.identifier.volume34en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBactericidal effecten_US
dc.subjectQuinupristin/dalfopristinen_US
dc.subjectStaphylococcus aureusen_US
dc.subjectVancomycinen_US
dc.titleInvestigation of the bactericidal effects of vancomycin and quinupristin/dalfopristin on Staphylococcus aureus isolatesen_US
dc.typeArticleen_US

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