A novel approach for skin infections: Controlled release topical mats of poly(lactic acid)/poly(ethylene succinate) blends containing Voriconazole

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dc.contributor.authorÜstündağ Okur N.
dc.contributor.authorFilippousi M.
dc.contributor.authorOkur M.E.
dc.contributor.authorAyla Ş.
dc.contributor.authorÇağlar E.
dc.contributor.authorYoltaş A.
dc.contributor.authorSiafaka P.I.
dc.date.accessioned2019-10-27T08:01:56Z
dc.date.available2019-10-27T08:01:56Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractThe oral and injectable formulations of Voriconazole (VRZ), a known antifungal agent with low solubility, seem to cause severe side effects. Consequently, topical application of VRZ could be advantageous for skin fungal infections. In this study, VRZ embedded in a polymeric matrix composed of biocompatible poly(lactic acid) (PLA) and poly(ethylene succinate) (PESu). The mats were prepared via solvent evaporation and fully characterized by Fourier-Transformed Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), Scanning Electron Microscopy (SEM), in vitro hydrolysis and release studies. The prepared blends defined as immiscible by DSC and SEM while FTIR spectroscopy did not disclose noticeable interactions between the polymers. It was found that hydrolysis was improved by increasing PESu content into the blend. VRZ loaded blends spectra exhibit slight differentiation compared to neat blends while the absence of VRZ melting peak, as DSC illustrated, indicated drug amorphization. Lastly, in vitro release studies depicted a controlled release pattern dependent on mats' hydrolysis degree. An improved antifungal activity of mats was detected by disc diffusion method against various microorganisms. Ex vivo studies of VRZ did not determine high permeation while histopathology results using mice were profitable. The irritation experiments displayed that the mats did not induce any skin irritation. © 2018en_US
dc.identifier.doi10.1016/j.jddst.2018.05.005
dc.identifier.endpage86en_US
dc.identifier.issn1773-2247
dc.identifier.issn1773-2247en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage74en_US
dc.identifier.urihttps://doi.org/10.1016/j.jddst.2018.05.005
dc.identifier.urihttps://hdl.handle.net/11454/25095
dc.identifier.volume46en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherEditions de Santeen_US
dc.relation.ispartofJournal of Drug Delivery Science and Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntifungalen_US
dc.subjectDressingen_US
dc.subjectDrug deliveryen_US
dc.subjectFungal infectionsen_US
dc.subjectTopical maten_US
dc.subjectVoriconazoleen_US
dc.titleA novel approach for skin infections: Controlled release topical mats of poly(lactic acid)/poly(ethylene succinate) blends containing Voriconazoleen_US
dc.typeArticleen_US

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