Formulation and Evaluation of Salbutamol Sulphate Tablets Prepared by Direct Compression Using Various Excipients: Statistical Comparison of Dissolution Methods and Tablet Properties

The tablet formulation of salbutamol sulphate (SBS), which is an antiasthmatic drug, was studied. It was aimed to investigate the effect of some excipients such as insoluble fillers and different disintegrants on the physical properties of salbutamol sulphate tablet formulations in this study. Meanwhile, the physical parameters and in vitro dissolution rates of SBS tablet avalaible on the Turkish drug market were also investigated. Apparatus I and II (USP XXIV) in the dissolution test and UV spectrophotometric method were used for the assay of the active substance. Paddle and basket dissolution test results were evaluated with DUNCAN test and a significant difference was found when compared statistically.