Nucleic acid based impedimetric biosensors

Analytical research related to (bio)sensors has gained an enormous growth since 1990s. Rapid, highly selective, and sensitive techniques to quantify biological and biochemical molecules and other target species are of great importance in biomedical application. Electrochemical biosensors based on impedance technique have been extremely useful for sensing of different types of biological interactions during the past years, due to their high sensitivity and fast response. A variety of sensing platforms in combination with electrochemical impedance spectroscopy as well as devices have been developed and still under progress. This chapter is focused on the development of impedimetric biosensors as functional sensing platforms for detection of nucleic acids by means of their excellent features such as portability, sensitivity, cost-effectiveness, easy to use and miniaturization, label-free operation, and on-site analysis. © 2023 Elsevier Ltd. All rights reserved.