Acquired Demyelinating Syndrome: Single Center Experience

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dc.contributor.authorSerin, Hepsen Mine
dc.contributor.authorSimsek, Erdem
dc.contributor.authorKanmaz, Seda
dc.contributor.authorYilmaz, Sanem
dc.contributor.authorAktan, Gul
dc.contributor.authorTekgul, Hasan
dc.contributor.authorGokben, Sarenur
dc.date.accessioned2019-10-27T09:47:29Z
dc.date.available2019-10-27T09:47:29Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: Acquired demyelinating syndromes are immune-mediated demyelinating disorders of the central nervous system. Clinical spectrum includes acute disseminated encephalomyelitis, optic neuritis, transverse myelitis, clinically isolated syndrome, and neuromyelitis optica. Aim of this study is to present the clinical features of patients followed up with the diagnosis of demyelinating disease other than multiple sclerosis and also our therapeutic experience. Method: Data of 30 patients with acquired demyelinating disease followed up in Ege University Department of Child Neurology between January 2013 and January 2018 were evaluated retrospectively. Demographic data, admission complaints, clinical and neuroimaging findings, laboratory results, ophthalmologic findings and treatments used were recorded. Results: The age of the patients ranged between 3, and 15 years and mean age was 8.76 +/- 3.59 years. The most common diagnosis was acute disseminated encephalomyelitis. The most common complaints were ataxia, headache, encephalopathy, plegia (mono+paraplegia), blurred vision and visual loss in order of decreasing frequency. Oligoclonal banding, and anti-aquaporin 4 antibody negativities were detected in all patients. Anti-myelin oligodendrocyte antibody-positivity was found in seven patients. In one of these patients tests were positive for both anti-aquaporin 4 and anti-myelin oligodendrocyte antibodies. Neuroimaging revealed findings consistent with cerebral white matter, spinal cord and optic nerve involvement. All patients were started on intravenous pulse methylprednisolone therapy during the acute episode Conclusion: Since childhood acquired demyelinating diseases may be the first episode of multiple sclerosis, it is important to perform detailed serological tests and CSF examinations for follow-up of patients, and differential diagnosis.en_US
dc.identifier.doi10.5222/buchd.2019.59023
dc.identifier.endpage100en_US
dc.identifier.issn2146-2372
dc.identifier.issn1309-9566
dc.identifier.issue2en_US
dc.identifier.startpage93en_US
dc.identifier.urihttps://doi.org/10.5222/buchd.2019.59023
dc.identifier.urihttps://hdl.handle.net/11454/29409
dc.identifier.volume9en_US
dc.identifier.wosWOS:000477890900003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isotren_US
dc.publisherDr Behcet Uz Cocuk Hastaliklari Ve Cerrahisien_US
dc.relation.ispartofIzmir Dr Behcet Uz Cocuk Hastanesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChildhooden_US
dc.subjectdemyelinating syndromeen_US
dc.subjectacute disseminated encephalomyelitisen_US
dc.subjectoptic neuritisen_US
dc.titleAcquired Demyelinating Syndrome: Single Center Experienceen_US
dc.typeArticleen_US

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