The association of plasma pancreastatin levels with insulin resistance in patients with gestational diabetes mellitus

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dc.authorscopusid57189902539
dc.authorscopusid35574673900
dc.authorscopusid26656445700
dc.authorscopusid58701491000
dc.authorscopusid57517774400
dc.authorscopusid58076185700
dc.authorscopusid57955663400
dc.contributor.authorUnal, Kocabas, G.
dc.contributor.authorYildirim, Simsir, I.
dc.contributor.authorSarer, Yurekli, B.
dc.contributor.authorSuner, Karakulah, A.
dc.contributor.authorDurmaz, B.
dc.contributor.authorPehlivan, Koroglu, E.
dc.contributor.authorYeral, S.
dc.date.accessioned2024-08-25T18:47:47Z
dc.date.available2024-08-25T18:47:47Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractIntroduction: Gestational diabetes mellitus (GDM) occurs on the background of increased insulin resistance. We aimed to investigate the levels of plasma pancreastatin (PST) levels and its association with metabolic, demographic, and anthropometric parameters in gestational diabetic and normal glucose-tolerant pregnant women. Materials and methods: A total of 165 pregnant women in the 24th–28th week of pregnancy were enrolled in this cross-sectional study. PST levels were measured using ELISA method. Results: Median PST levels were similar between GDM (n = 62, 37.6%) and normal glucose-tolerant control group (n = 103, 62.4%). In the GDM group, PST level showed a significant positive correlation with fasting insulin and the homeostasis model assessment of insulin resistance (HOMA-IR). In binary logistic regression analysis, PST levels did not predict the presence of GDM significantly. Conclusion: Positive correlation of PST with fasting insulin and HOMA-IR suggests that PST could be associated with insulin resistance. Further studies are needed as regards to the role of PST in GDM pathogenesis. © The Author(s) 2023.en_US
dc.description.sponsorshipEge Üniversitesien_US
dc.identifier.doi10.1177/1753495X231216032
dc.identifier.issn1753-495X
dc.identifier.scopus2-s2.0-85177225176en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1177/1753495X231216032
dc.identifier.urihttps://hdl.handle.net/11454/102030
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSAGE Publications Inc.en_US
dc.relation.ispartofObstetric Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240825_Gen_US
dc.subjectgestational diabetes mellitusen_US
dc.subjectinsulin resistanceen_US
dc.subjectPancreastatinen_US
dc.titleThe association of plasma pancreastatin levels with insulin resistance in patients with gestational diabetes mellitusen_US
dc.typeArticleen_US

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