In vitro determination of wound healing potential of axonge

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dc.contributor.authorBilgi A.
dc.contributor.authorMuftuler F.Z.B.
dc.contributor.authorAkman L.
dc.contributor.authorMedine E.I.
dc.contributor.authorBilgi P.T.
dc.contributor.authorGuldu O.K.
dc.contributor.authorGokulu S.G.
dc.contributor.authorTekin V.
dc.contributor.authorTerek M.C.
dc.date.accessioned2019-10-26T21:16:26Z
dc.date.available2019-10-26T21:16:26Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: Research on treatment alternatives that improve wound healing is an ever-evolving area in medicine, and a wound healing agent that carries minimal pain, discomfort, and scarring for patients with burn wounds, venous and decubitis ulcers, traumatic wounds, and many others is needed. The phases of wound healing include homeostasis, inflammation, migration, proliferation, and maturation. Adeps suillus (axonge) is known as a therapeutic agent for skin diseases and mainly consists of triglycerides. Objective: In the current study, the proliferation effect of axonge was determined on human normal epidermal keratinocyte (HaCaT) cells and human normal foreskin fibroblast cell line (BJ) cells. Materials and Methods: Experimental steps included preparation of HaCaT and BJ cell lines, axonge's stable tetrazolium salt-based proliferation assay, and evaluation of the wound healing effect of axonge on HaCaT and BJ cells. Results: Axonge concentrations of 3.12 µg/mL, 6.25 µg/mL, 12.5 µg/mL, 25 µg/mL, and 50 µg/mL showed no cytotoxic effect on both HaCaT and BJ cells for 24, 48, and 72 hours. Considering the wound area of HaCaT cells, after 6 hours the wound healing effect of the axonge group reached almost 70% and then stopped. According to the results of the study on BJ cells, after 6 hours axonge wound closure was found to be 50% while the control group was only 10%. Conclusion: On the basis of this study, the authors determined that axonge might have potential for use in wound healing. © 2017 HMP Communications. All rights reserved.en_US
dc.identifier.endpage214en_US
dc.identifier.issn1044-7946
dc.identifier.issn1044-7946en_US
dc.identifier.issue7en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage209en_US
dc.identifier.urihttps://hdl.handle.net/11454/16197
dc.identifier.volume29en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherHMP Communicationsen_US
dc.relation.ispartofWoundsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdeps suillusen_US
dc.subjectAxongeen_US
dc.subjectHaCaT cellsen_US
dc.subjectProliferationen_US
dc.subjectWound healingen_US
dc.titleIn vitro determination of wound healing potential of axongeen_US
dc.typeArticleen_US

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