A Single-Center Retrospective Evaluation of The Incidence and Survival of Invasive Fungal Infection in Allogeneic Stem Cell Transplant Patients

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dc.authorid0000-0003-1659-3392
dc.authorid0000-0002-7722-506X
dc.authorid0000-0001-5939-4989
dc.authorid0000-0001-9315-8891
dc.authorid0000-0001-8646-1673
dc.authorid0000-0002-4388-5975
dc.authorid0000-0003-3489-296X
dc.contributor.authorOsabas, Emre
dc.contributor.authorGunes, Ajda
dc.contributor.authorSoyer, Nur
dc.contributor.authorTobu, Mahmut
dc.contributor.authorSahin, Fahri
dc.contributor.authorSaydam, Guray
dc.contributor.authorArda, Bilgin
dc.contributor.authorVural, Filiz
dc.date.accessioned2025-03-06T07:48:18Z
dc.date.available2025-03-06T07:48:18Z
dc.date.issued2024
dc.departmentEge Üniversitesi, Tıp Fakültesi, Dahili Bilimler Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractAim: The incidence of invasive fungal infection (IFI) is high in patients undergoing allogeneic hematopoietic stem cell transplantation. Despite new antifungal agents, IFI is still an important cause of mortality. Our study aimed to determine the risk factors of IFI and its effect on mortality. Materials and Methods: One hundred and fifty-four patients who underwent allogeneic transplantation were included in the study. Demographic characteristics, underlying disease, transplantation characteristics, and IFI status of all patients were evaluated retrospectively. The study group was divided into two: 75 patients with definite, high probability and possible IFI (group 1) and 79 patients without IFI (group 2) according to the criteria of the international committee. Results: Of 154 patients, 92 were male (59.7%) and 62 were female (40.3%) with a mean age of 41.87 +/- 14.04 years (range: 18-67 years). The most common transplant indication was acute myeloid leukemia in 58 patients (37.7%). In the analyzes performed on two groups, more IFI were observed in those who had acute graft-versus-host disease after transplantation (p= 0.035) and in those with CMV reactivation (p=0.002). The mean neutropenia duration was 30.89 +/- 20.40 in group 1 and 19.98 +/- 11.01 in group 2 (p=0.001). Underlying diseases, preparation regimen, donor compatibility, consanguineous marriage and IFI history were not found to be significant in terms of the development of IFI. The mortality rate due to IFI was found to be 24%. The mean duration of neutropenia was found to be longer in patients who died (p=0.02). Conclusion: In our study, the frequency of IFI, risk factors and mortality rates were found to be similar to the literature. It would be appropriate for each center to evaluate the frequency of IFI and the risk factors that increase it and decide which treatment strategy is more beneficial for their patients.
dc.identifier.citationODABAŞ, E., GÜNEŞ, A., SOYER, N., TOBU, M., ŞAHİN, F., SAYDAM, G., ARDA, B., & VURAL, F. (2024). A single-center retrospective evaluation of the incidence and survival of invasive fungal infection in allogeneic stem cell transplant patients. Namık Kemal Tıp Dergisi, 12(4), 310-317.
dc.identifier.doi10.4274/nkmj.galenos.2024.25152
dc.identifier.endpage317
dc.identifier.issue4
dc.identifier.startpage310
dc.identifier.urihttps://doi.org/10.4274/nkmj.galenos.2024.25152
dc.identifier.urihttps://hdl.handle.net/11454/116462
dc.identifier.volume12
dc.identifier.wosWOS:001390188800001
dc.indekslendigikaynakWeb of Science
dc.institutionauthorGunes, Ajda
dc.institutionauthorSoyer, Nur
dc.institutionauthorTobu, Mahmut
dc.institutionauthorSahin, Fahri
dc.institutionauthorSaydam, Guray
dc.institutionauthorArda, Bilgin
dc.institutionauthorVural, Filiz
dc.institutionauthorid0000-0003-1659-3392
dc.institutionauthorid0000-0002-7722-506X
dc.institutionauthorid0000-0001-5939-4989
dc.institutionauthorid0000-0001-9315-8891
dc.institutionauthorid0000-0001-8646-1673
dc.institutionauthorid0000-0002-4388-5975
dc.institutionauthorid0000-0003-3489-296X
dc.language.isoen
dc.publisherGalenos Publishing House
dc.relation.ispartofNamık Kemal Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAllogeneic transplantation
dc.subjectinvasive fungal infections
dc.subjectrisk factors
dc.subjectmortality markers
dc.titleA Single-Center Retrospective Evaluation of The Incidence and Survival of Invasive Fungal Infection in Allogeneic Stem Cell Transplant Patients
dc.typeArticle

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