Synthesis of a 99mTc labeled estrogen-derivative and the determination of its radiopharmaceutical potential on rats

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dc.contributor.authorEnginar H.
dc.contributor.authorUnak P.
dc.contributor.authorYurt Lambrecht F.
dc.contributor.authorBiber F.Z.
dc.date.accessioned2019-10-27T08:59:25Z
dc.date.available2019-10-27T08:59:25Z
dc.date.issued2004
dc.departmentEge Üniversitesien_US
dc.description.abstractAn estrogen derivative 1-(3, 17-?-estradiolyl propin-1-yl-3-(1,4,8, 11-tetraazacyclotetradecyl)-propanate (ESTACPA) was synthesized. The product was purified by HPLC and characterized by NMR and IR spectroscopy. The synthesized compound was labeled with 99mTc. The biodistribution studies were performed on female Albino Wistar rats. The rats were sacrificed and their organs were removed. The radioactivities of the organs were counted using a gamma-counter. The activity per gram tissue was calculated and time versus activity curves were generated. The 99mTc-ESTACPA uptake by the uterus and ovary such as ER-rich tissues, were observed. The pancreas and stomach also showed a significant uptake.en_US
dc.description.sponsorshipInternational Atomic Energy Agencyen_US
dc.description.sponsorshipThe authors thanks for the financial supports from Ege University Research Funds, Afyon Kocatepe University Research Fund and International Atomic Energy Agency (IAEA) and The Scientific and Technical Research Council of Turkey. They are grateful to Schering Alman Ilac Ecza Ticaret Ltd. for supplying the ethynyl estradiol as a gift for chemical synthesis and also Dr. Cavit KAZAZ from Atatürk University at Erzurum-Turkey for kind assistance in the NMR analyses. Dr. Mahmoud ASLANI and B. ÇETINKAYA are acknowledged for their helpful assistance. --en_US
dc.identifier.doi10.1023/B:JRNC.0000027107.43043.37
dc.identifier.endpage349en_US
dc.identifier.issn0236-5731
dc.identifier.issn0236-5731en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage339en_US
dc.identifier.urihttps://doi.org/10.1023/B:JRNC.0000027107.43043.37
dc.identifier.urihttps://hdl.handle.net/11454/27798
dc.identifier.volume260en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Radioanalytical and Nuclear Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleSynthesis of a 99mTc labeled estrogen-derivative and the determination of its radiopharmaceutical potential on ratsen_US
dc.typeArticleen_US

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