Evaluation of bone mineral density and related parameters in patients with haemophilia: a single center cross-sectional study

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dc.contributor.authorUnal, Hatice Demet Kiper
dc.contributor.authorOzkan, Melda Comert
dc.contributor.authorAtilla, Fatos Dilan
dc.contributor.authorDemirci, Zuhal
dc.contributor.authorSoyer, Nur
dc.contributor.authorSimsir, Ilgin Yildirim
dc.contributor.authorOmur, Ozgur
dc.contributor.authorCapaci, Kazim
dc.contributor.authorSaydam, Güray
dc.contributor.authorSahin, Fahri
dc.date.accessioned2019-10-27T11:19:34Z
dc.date.available2019-10-27T11:19:34Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractHaemophilia has been associated with low bone mineral density (BMD) probably due to some predisposing factors. The aim of this study was to evaluate the relationship between BMD and potential clinical predictors in adult haemophilic patients. Fortynine patients with moderate and severe haemophilia were enrolled. BMD was measured by Dual Energy X-Ray Absorptiometry (DXA) and blood tests were performed for vitamin D, calcium, phosphore, alkaline phosphatase and parathormone levels. Functional Independence Score in Haemophilia (FISH) and Haemophilia Joint Health Score (HJHS) were used to assess musculoskeletal functions. Body mass index (BMI), Hepatitis C virus (HCV)/Human immunodeficiency virus (HIV) seropositivity and smoking status were also recorded. BMD was found lower than expected for reference age in 34.8% of patients of less than 50 years old. In patients older than 50 years, 66.6% of them had osteoporosis and 33.3% of them had normal BMD. FISH score was statistically significant correlated with BMD of total hip (TH) and femur neck (FN) but not with lumbar spine (LS). In eligible patients, there was also a statistically significant correlation between BMD of TH and HJHS. Vitamine D deficiency was common and found in 77.5% of patients, although there was no significant correlation with BMD. Also no correlation was found between BMD and blood tests, HCV/HIV status, BMI and smoking. This study confirmed that patients with haemophilia have an increased prevelance of low BMD even in younger group. Our results showed that there are significant correlations between FISH score and BMD of TH and FN and also between HJHS score and BMD of TH. Thus, using scoring systems may be beneficial as a simple predictors of BMD to reflect the severity of haemophilic arthropathy.en_US
dc.description.sponsorshipEge University Medical Faculty Research Project SubcommitteeEge University [2014/TIP/032]en_US
dc.description.sponsorshipWe acknowledge that this study was supported by Ege University Medical Faculty Research Project Subcommittee (Grant number: 2014/TIP/032).en_US
dc.identifier.issn2160-1992
dc.identifier.issn2160-1992en_US
dc.identifier.issue5en_US
dc.identifier.urihttps://hdl.handle.net/11454/32792
dc.identifier.volume7en_US
dc.identifier.wosWOS:000415652800002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherE-Century Publishing Corpen_US
dc.relation.ispartofAmerican Journal of Blood Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHaemophiliaen_US
dc.subjectbone mineral densityen_US
dc.subjectosteoporosisen_US
dc.subjectFISHen_US
dc.subjectHJHSen_US
dc.titleEvaluation of bone mineral density and related parameters in patients with haemophilia: a single center cross-sectional studyen_US
dc.typeArticleen_US

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