Electroencapsulation of Trans-resveratrol in Nanoparticles Composed of Silk Fibroin and Soluble Eggshell Membrane Protein

Basit Öğe Kaydı
dc.contributor.authorBayraktar, Oguz
dc.contributor.authorYahsi, Yasemin
dc.contributor.authorKose, Merve Deniz
dc.date.accessioned2021-05-03T20:28:08Z
dc.date.available2021-05-03T20:28:08Z
dc.date.issued2021
dc.departmentEge Üniversitesien_US
dc.description.abstractThe beneficial effects of trans-resveratrol on health are widely accepted. However, when exposed to heat and UV light, the degradation of trans-resveratrol to less active form cis-resveratrol limits its use in industrial applications. Due to this reason, it is crucial to preserve the stability of trans-resveratrol by using carrier systems. This study aimed to encapsulate the trans-resveratrol in core/shell nanoparticles composed of eggshell membrane proteins and silk fibroin, respectively, using a coaxial electrospraying technique to preserve its stability. The size of the nanoparticles ranged from 8.2 to 254 nm. Keeping the encapsulation yield at the maximum level (96.9%), electroencapsulation process parameters which minimize the average particle diameter (23.8 nm) were found to be A (silk fibroin concentration) = 30.7 mg/ml, B (ratio of flow rates) = 0.72, C (applied voltage) = 18.8 kV, and D (distance) = 12.2 cm. Encapsulation efficiency varied between 40.05 and 96.41%. Detection of antioxidant capacity of released trans-resveratrol suggested that nanoparticles could be a suitable delivery system for sustained release of trans-resveratrol with preserved thermal and UV photostability. Central composite design (CCD) and the response surface methodology (RSM) were successfully used to optimize the electroencapsulation process parameters for the preparation of trans-resveratrol loaded core/shell nanoparticles. It was found that these parameters seemed to be varied depending on the response required. Therefore, an optimum process should be investigated to obtain desired responses such as high encapsulation yield, high encapsulation efficiency, and small average particle size while preserving the thermal and UV stabilities at reasonable levels.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [116M566]en_US
dc.description.sponsorshipThis research was supported by the Scientific and Technological Research Council of Turkey (TUBITAK) under grant number 116M566.en_US
dc.identifier.doi10.1007/s11947-020-02576-w
dc.identifier.endpage351en_US
dc.identifier.issn1935-5130
dc.identifier.issn1935-5149
dc.identifier.issn1935-5130en_US
dc.identifier.issn1935-5149en_US
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85100165185en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage334en_US
dc.identifier.urihttps://doi.org10.1007/s11947-020-02576-w
dc.identifier.urihttps://hdl.handle.net/11454/69753
dc.identifier.volume14en_US
dc.identifier.wosWOS:000607984700001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofFood and Bioprocess Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectResveratrolen_US
dc.subjectEggshell membraneen_US
dc.subjectSilk fibroinen_US
dc.subjectElectroencapsulationen_US
dc.subjectNanoparticleen_US
dc.titleElectroencapsulation of Trans-resveratrol in Nanoparticles Composed of Silk Fibroin and Soluble Eggshell Membrane Proteinen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu