Unveiling combat strategies against Candida spp. biofilm structures: Demonstration of photodynamic inactivation with innovative phthalocyanine derivatives

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dc.authoridYurt, Fatma/0000-0002-9394-6908
dc.contributor.authorOzturk, Ismail
dc.contributor.authorOzel, Derya
dc.contributor.authorDogan, Sifa
dc.contributor.authorTuncel, Ayca
dc.contributor.authorYurt, Fatma
dc.contributor.authorTekintas, Yamac
dc.contributor.authorDemircioglu, Perihan Kubra
dc.date.accessioned2024-08-31T07:47:04Z
dc.date.available2024-08-31T07:47:04Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractAntimicrobial resistance is an important problem for infection control and therapy. Microorganisms in biofilm structure are remarkably less susceptible to antimicrobials compared to planktonic cells. Increasing rates of resistance to antimicrobials have led to the development of new antimicrobial strategies. Antimicrobial photodynamic therapy (PDT) is an alternative treatment method that may contribute to the fields of infection control and treatment. This study aimed to investigate the antifungal activities of photosensitizers and the anti -biofilm activities of phthalocyanine derivatives on C. albicans and C. parapsilosis strains. The anti -biofilm effects of aPDT on the biofilm of Candida albicans were also visualized via SEM (Scanning Electron Microscopy). Our findings showed that aPDT with phthalocyanines inhibited biofilm production levels and reduced the mature biofilm levels of Candida strains. Additionally, SEM results supported that aPDT application successfully eradicated fungal cells and inhibited the biofilm produced by C. albicans . Although more detailed experiments are needed, we suggest that the use of Pcs in aPDT may be beneficial for the treatment of biofilm-related Candida infections.en_US
dc.identifier.doi10.1016/j.jphotochem.2024.115746
dc.identifier.issn1010-6030
dc.identifier.issn1873-2666
dc.identifier.scopus2-s2.0-85192228942en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.jphotochem.2024.115746
dc.identifier.urihttps://hdl.handle.net/11454/104300
dc.identifier.volume454en_US
dc.identifier.wosWOS:001239526100001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Saen_US
dc.relation.ispartofJournal of Photochemistry and Photobiology A-Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240831_Uen_US
dc.subjectAntimicrobial Photodynamic Therapyen_US
dc.subjectCandida Albicansen_US
dc.subjectCandida Parapsilosisen_US
dc.subjectBiofilmen_US
dc.subjectAnti -Biofilm Activityen_US
dc.subjectPhthalocyaninesen_US
dc.titleUnveiling combat strategies against Candida spp. biofilm structures: Demonstration of photodynamic inactivation with innovative phthalocyanine derivativesen_US
dc.typeArticleen_US

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