Novel glyconanoconjugates: synthesis, characterization and bioapplications

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dc.contributor.authorTelli, Fatma Cetin
dc.contributor.authorDemir, Bilal
dc.contributor.authorBarlas, Firat Baris
dc.contributor.authorGuler, Emine
dc.contributor.authorTimur, Suna
dc.contributor.authorSalman, Yesim
dc.date.accessioned2019-10-27T22:57:46Z
dc.date.available2019-10-27T22:57:46Z
dc.date.issued2016
dc.departmentEge Üniversitesien_US
dc.description.abstractThe impressive properties of nanoparticles (NPs) have caused them to gain considerable attention for biological applications such as cancer therapy. Among the many nanoparticles used in the treatment of cancer, carbohydrate derivatized modified NPs lead the way with enhanced internalization and therapy efficacy for cancerous cell lines. In this research, an aminochlorase Schiff base, which can be beneficial as a therapy material, with a galactose residue was used as a potentially active modifier. Gold and silver nanoparticles (AuNPs and AgNPs) can be readily modified with a sugar Schiff base ligand (1) by using cysteamine hydrochloride residues as a linker between the nanoparticle surface and the ligand. The resulting glyco-nanoparticles were characterized using transmission electron microscopy, X-ray photoelectron microscopy and spectrophotometric techniques. Additionally, this modification type within a galactose derived Schiff base is the first work with a bioapplication, especially in radiotherapy. For further biological applications in cancerous cell lines, two commonly used cell lines, human cervix adenocarcinoma (HeLa) and human lung carcinoma cell line (A549) were introduced into the biological evaluation of those NP-ligand conjugates and satisfactory radioactivity results were obtained because of the radiosensitizing effect of the AuNPs and AgNPs.en_US
dc.identifier.doi10.1039/c6ra21976d
dc.identifier.endpage105813en_US
dc.identifier.issn2046-2069
dc.identifier.issn2046-2069en_US
dc.identifier.issue107en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage105806en_US
dc.identifier.urihttps://doi.org/10.1039/c6ra21976d
dc.identifier.urihttps://hdl.handle.net/11454/51321
dc.identifier.volume6en_US
dc.identifier.wosWOS:000388116500100en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherRoyal Soc Chemistryen_US
dc.relation.ispartofRsc Advancesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleNovel glyconanoconjugates: synthesis, characterization and bioapplicationsen_US
dc.typeArticleen_US

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