Roles of 5,10-methylenetetrahydrofolate reductase C677T and A1298C polymorphisms in early- and late-onset obsessive-compulsive disorder

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dc.contributor.authorCaliskan M.
dc.contributor.authorOrenay-Boyacioglu S.
dc.contributor.authorDondu A.
dc.date.accessioned2019-10-27T08:01:08Z
dc.date.available2019-10-27T08:01:08Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: The C677T and A1298C mutations of 5,10-methylenetetrahydrofolate reductase (MTHFR) have been linked with conditions such as depression, bipolar disorder, and schizophrenia, but there are not clear the relationship between MTHFR polymorphisms and obsessive-compulsive disorder (OCD). Aim: The current study was planned to investigate the link between the MTHFR polymorphisms and OCD in patients to reveal any potential correlations that may be used as a novel marker in diagnosis of people who are in high-risk group of developing OCD. Materials and Methods: Blood samples from 64 highly characterized symptomatic cases and 64 gender- and age-matched control participants were analyzed for MTHFR C677T and A1298C gene variants. The MTHFR gene polymorphisms were detected through real-time polymerase chain reaction, followed by melting curve analysis. The results were tested with analysis of variance test and the differences with P < 0.05 were reported as statistically significant. Results: A statistically significant difference in age, education level, and marital status was found in the comparison of all groups in sociodemographic findings (P = 0.004, P = 0.001, and P = 0.001, respectively). A statistically significant difference was found in the comparison of the tic story of early- and late-onset OCD patients (P = 0.002). There was no significant difference in the genotype frequencies and allele distributions of MTHFR polymorphisms between the patients and controls (P > 0.05). Conclusion: The results suggest that MTHFR polymorphisms are unlikely to play a major role in the pathogenesis of OCD. Further studies are needed in biochemical data on folate metabolism to clarify the effect of the MTHFR polymorphisms in OCD pathophysiology. © 2019 Indian Journal of Psychiatry Published by Wolters Kluwer - Medknow.en_US
dc.identifier.doi10.4103/psychiatry.IndianJPsychiatry_370_18
dc.identifier.endpage166en_US
dc.identifier.issn0019-5545
dc.identifier.issn0019-5545en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage161en_US
dc.identifier.urihttps://doi.org/10.4103/psychiatry.IndianJPsychiatry_370_18
dc.identifier.urihttps://hdl.handle.net/11454/24919
dc.identifier.volume61en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofIndian Journal of Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject510-methylenetetrahydrofolate reductase gene polymorphismsen_US
dc.subjectearly-onset obsessive-compulsive disorderen_US
dc.subjectfolate metabolismen_US
dc.subjectlate-onset obsessive-compulsive disorderen_US
dc.titleRoles of 5,10-methylenetetrahydrofolate reductase C677T and A1298C polymorphisms in early- and late-onset obsessive-compulsive disorderen_US
dc.typeArticleen_US

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