Evaluation of Insulin Resistance by the Homeostasis Model Assessment in Female Patients with Primary Sjogren's Syndrome

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dc.contributor.authorKarabulut, Gonca
dc.contributor.authorSarac, Fulden
dc.contributor.authorKitapcioglu, Gul
dc.contributor.authorYilmaz, Candeger
dc.contributor.authorKabasakal, Yasemin
dc.date.accessioned2019-10-27T21:36:25Z
dc.date.available2019-10-27T21:36:25Z
dc.date.issued2011
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: To evaluate insulin resistance in Primary Sjogren's Syndrome (pSS) using homeostasis model assessment (HOMA) method Design: Cross-sectional study conducted between January 2006 and December 2008 Setting: Ege University Faculty of Medicine, Izmir, Turkey Subjects: Thirty-five female patients with pSS fulfilling the US-European Consensus Criteria Interventions: A brief clinical history, demographic, anthropometric, clinical and laboratory profiles were recorded Main Outcome Measures: HOMA-IR and serum lipid levels Results: Mean level of HOMA-IR was 1.8 +/- 0.7 in patients with pSS. Mean levels of plasma fasting glucose and insulin were 90.6 +/- 7.1 mg/di, 7.8 +/- 2.5 microU/1, respectively. A statistically significant difference was detected between ANA positivity and HOMA-IR values (p = 0.016). Four patients with pSS had high HOMA values (> 2.7) and all these patients had ANA positivity. A statistically significant positive correlation was detected between HOMA-IR values and HDL-C levels (R = 0,450 p = 0.009). However, a statistically significant difference was detected between extraglandular involvement and LDL-C (p = 0.01) and total cholesterol levels (p = 0.01). Patients who had no extraglandular involvement had higher levels of total cholesterol and LDLC levels. Lower triglyceride levels were seen in patients with anti-La antibodies (p = 0.01) but not other antibodies (p > 0.05). Patients with ANA positivity and pSS had lower LDLC levels (p = 0.009). Conclusion: Autoimmune mechanisms may play a role in insulin resistance in pSS. Metabolic alterations should be taken into account in their management.en_US
dc.identifier.endpage223en_US
dc.identifier.issn0023-5776
dc.identifier.issn0023-5776en_US
dc.identifier.issue3en_US
dc.identifier.startpage220en_US
dc.identifier.urihttps://hdl.handle.net/11454/46052
dc.identifier.volume43en_US
dc.identifier.wosWOS:000295909900008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherKuwait Medical Assocen_US
dc.relation.ispartofKuwait Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHOMAen_US
dc.subjectinsulin resistanceen_US
dc.subjectSjogren's syndromeen_US
dc.titleEvaluation of Insulin Resistance by the Homeostasis Model Assessment in Female Patients with Primary Sjogren's Syndromeen_US
dc.typeArticleen_US

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