A marked difference between two populations under mass screening of neonatal TSH and biotinidase activity

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dc.contributor.authorTanyalcin, T
dc.contributor.authorEyskens, F
dc.contributor.authorPhilips, E
dc.contributor.authorLefevere, M
dc.contributor.authorBuyukgebiz, B
dc.date.accessioned2019-10-27T18:42:43Z
dc.date.available2019-10-27T18:42:43Z
dc.date.issued2002
dc.departmentEge Üniversitesien_US
dc.descriptionEuropean Conference on Quality in the Spotlight in Medical Laboratories -- OCT 07-09, 2001 -- ANTWERP, BELGIUMen_US
dc.description.abstractHealth-associated reference values are universally needed in clinical chemistry. The aim of this study was to establish the reference intervals of two populations from data obtained by the mass screening of newborn babies and to demonstrate how to determine 95% confidence intervals around the lower and upper limits of reference values from values that are not normally distributed. Biotinidase activities from Belgian (n=260) and Turkish (n=328) populations were measured by fluorometric assay and expressed as 1 IU (1 nmol/(dl min). Neonatal thyroid-stimulating hormone (nTSH) values from Belgian (n=4186) and Turkish (n=1663) populations were also measured by the solid phase two-site fluoroimmunometric assay, the results were given as muU/ml blood. Transformation of data was performed for each parameter. A parametric method was used for determination of reference values of biotinidase activity and the Belgian population was significantly higher than the Turkish population. nTSH reference values were evaluated by an exact non-parametric method, but approximate calculation based on the central limit theorem was also performed for confidence intervals around the reference limits. nTSH values of the Turkish population were found to be significantly higher than for the Belgian population. Rank numbers were found by an exact non-parametric method based upon the assumption of a binomial distribution. This study shows a procedure to define the rank numbers for n>1000 and to obtain reference values with 95% confidence intervals for lower and upper reference limits.en_US
dc.identifier.doi10.1007/s00769-002-0546-z
dc.identifier.endpage506en_US
dc.identifier.issn0949-1775
dc.identifier.issn0949-1775en_US
dc.identifier.issue11en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage498en_US
dc.identifier.urihttps://doi.org/10.1007/s00769-002-0546-z
dc.identifier.urihttps://hdl.handle.net/11454/37149
dc.identifier.volume7en_US
dc.identifier.wosWOS:000179781300013en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringer-Verlagen_US
dc.relation.ispartofAccreditation and Quality Assuranceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectmass screeningen_US
dc.subjectconfidence limitsen_US
dc.subjectreference valuesen_US
dc.titleA marked difference between two populations under mass screening of neonatal TSH and biotinidase activityen_US
dc.typeArticleen_US

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