Glutathione Encapsulation in Core-Shell Drug Nanocarriers (Polymersomes and Niosomes) Prevents Advanced Glycation End-products Toxicities

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dc.authoridGhorbanizamani, Faezeh/0000-0001-8541-0540
dc.authoridMOULAHOUM, Hichem/0000-0003-3934-6415
dc.authoridTimur, Suna/0000-0002-1981-7577
dc.authoridBayir, Ece/0000-0003-4886-3860
dc.authoridZIHNIOGLU, FIGEN/0000-0001-8216-7004
dc.authorscopusid57199103659
dc.authorscopusid57188963997
dc.authorscopusid56305170300
dc.authorscopusid6602258835
dc.authorscopusid6701638388
dc.authorwosidGhorbanizamani, Faezeh/ABE-3800-2021
dc.authorwosidMOULAHOUM, Hichem/DIC-3335-2022
dc.authorwosidBayir, Ece/E-9908-2015
dc.authorwosidTimur, Suna/CAG-0914-2022
dc.contributor.authorGhorbanizamani, Faezeh
dc.contributor.authorMoulahoum, Hichem
dc.contributor.authorBayir, Ece
dc.contributor.authorZihnioglu, Figen
dc.contributor.authorTimur, Suna
dc.date.accessioned2023-01-12T19:50:44Z
dc.date.available2023-01-12T19:50:44Z
dc.date.issued2021
dc.departmentN/A/Departmenten_US
dc.description.abstractThe clinical application of some natural molecules in therapy is usually limited due to the lack of feasible delivery systems. Core-shell nanocarriers (polymersomes and niosomes) are interesting stable nanocarriers that are biocompatible, biodegradable, and able to produce sustainable delivery. They can be modified and functionalized according to the application needed. In this report, we describe the synthesis of a smart and pH-responsive poly(ethylene oxide)-poly(lactide) polymersome (PEO-PL) and niosomes (NIO) loaded with GSH for efficient peptide delivery and potent application against advanced glycation end-products-related damages and toxicities. PEO-PL was constructed using the one-pot sequential anionic ring-opening polymerization method, while the niosomes were prepared via the thin film layer technique. The nanocarriers were characterized for their size and morphology by DLS and SEM. The formulations demonstrated a high encapsulation rate reaching 95% and showed increased sensitivity to release their content in acidic conditions (pH 5.5) compared with physiological media. PEO-PL showed a higher retention rate compared with the NIO. The nanocarriers showed no apparent toxicity even at high concentrations (400 mu g/mL). The MTT test demonstrated that HeLa cell lines were more sensitive to GSH than U87 cell lines starting from 100 and 400 mu g/mL, respectively. Testing the synthesized core-shell nanocarriers on altered proteins showed prolonged and high prevention rates of glycation, aggregation, and oxidation without hindering the effect of GSH. These bioresponsive nanocarriers appear as an interesting platform for biomedicine and therapy.en_US
dc.identifier.doi10.1007/s10989-021-10291-z
dc.identifier.endpage2821en_US
dc.identifier.issn1573-3149
dc.identifier.issn1573-3904
dc.identifier.issn1573-3149en_US
dc.identifier.issn1573-3904en_US
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85115707161en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage2809en_US
dc.identifier.urihttps://doi.org/10.1007/s10989-021-10291-z
dc.identifier.urihttps://hdl.handle.net/11454/76160
dc.identifier.volume27en_US
dc.identifier.wosWOS:000699000500001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofInternational Journal Of Peptide Research And Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdvanced glycation end-productsen_US
dc.subjectCore-shell nanocarrieren_US
dc.subjectNiosomeen_US
dc.subjectPolymersomeen_US
dc.subjectLactideen_US
dc.subjectDelivery-Systemsen_US
dc.subjectNanoparticlesen_US
dc.subjectOxidationen_US
dc.subjectEfficienten_US
dc.subjectReleaseen_US
dc.titleGlutathione Encapsulation in Core-Shell Drug Nanocarriers (Polymersomes and Niosomes) Prevents Advanced Glycation End-products Toxicitiesen_US
dc.typeArticleen_US

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