Hyponatremia in Children with Acute Lymphoblastic Leukemia

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dc.contributor.authorKarapinar, Deniz Yilmaz
dc.contributor.authorSahin, Akkiz
dc.contributor.authorOzen, Selime
dc.contributor.authorOzkaya, Pinar Yazici
dc.contributor.authorSivis, Zuhal Onder
dc.contributor.authorAkinci, Ayse Burcu
dc.contributor.authorKarapinar, Bulent
dc.date.accessioned2020-12-01T12:01:09Z
dc.date.available2020-12-01T12:01:09Z
dc.date.issued2020
dc.departmentEge Üniversitesien_US
dc.description.abstractAim: Hyponatremia is a common electrolyte abnormality in hospitalized patients. Administration of isotonic maintenance fluids is recommended to prevent hyponatremia. the present study was conducted to evaluate the frequency and severity of hyponatremia in children with acute lymphoblastic leukemia (ALL). Materials and Methods: the frequency, severity and possible causes of hyponatremia in children with ALL throughout their entire intensive treatment were retrospectively evaluated. All children in this study received isotonic fluids as maintenance IV treatment during the hospitalization period. Results: in a five-year period, 618 hyponatremia episodes seen in 92 children with ALL (median age 59 months), treated with ALLIC 2002 protocol were entered into the study. the median number of hyponatremia episodes per patient was 6. All patients had at least one hyponatremia episode of which 83.2% were classified as mild, 13.2% as moderate, 2.9% as severe and 0.6% as very severe. the median duration of hyponatremia episodes was 5 (range between 1-43) days. the total duration of all hyponatremia episodes of each patient varied from 6 to 138 days with a median of 30 days. in 241 episodes of 68 children, there was inadequate salt intake secondary to oral feeding intolerance, nausea, vomiting and oral aphthous stomatitis. in four patients, seizure was seen during the hyponatremia period and thought to be secondary to hyponatremic encephalopathy. No patient developed central pontine myelinolysis. Conclusion: Hyponatremia is very frequent in ALL patients. Despite the use of isotonic IV fluids, it seems it cannot be completely prevented.en_US
dc.identifier.doi10.4274/jpr.galenos.2019.46547
dc.identifier.endpage145en_US
dc.identifier.issn2147-9445
dc.identifier.issn2147-9445en_US
dc.identifier.issue2en_US
dc.identifier.startpage139en_US
dc.identifier.urihttps://doi.org/10.4274/jpr.galenos.2019.46547
dc.identifier.urihttps://hdl.handle.net/11454/62323
dc.identifier.volume7en_US
dc.identifier.wosWOS:000533660200011en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofJournal of Pediatric Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHyponatremiaen_US
dc.subjectchildrenen_US
dc.subjectacute lymphoblastic leukemiaen_US
dc.subjectisotonic fluiden_US
dc.titleHyponatremia in Children with Acute Lymphoblastic Leukemiaen_US
dc.typeArticleen_US

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