An oestrogen-derivative labeled with Tc-99m and its radiopharmaceutical potential

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dc.contributor.authorEnginar, H
dc.contributor.authorUnak, P
dc.contributor.authorYurt, F
dc.contributor.authorBiber, FZ
dc.date.accessioned2019-10-27T18:18:16Z
dc.date.available2019-10-27T18:18:16Z
dc.date.issued2002
dc.departmentEge Üniversitesien_US
dc.description.abstractAn oestrogen derivative 3,17-alpha-oestradiolyl propyl 1.4,8,11-tetraazacyclotetradecanyl-1-(4-methylbenzoic acid)ester (ESTCPTA) that is 3,17-alpha-oestradiolyl propinol coupled to 1-(4-methylbenzoic acid) 1,4,8,1 1-tetraazacyclotetradecane (CPTA) was synthesized in five steps. The product was purified by recrystallization in ethyl alcohol, and analysed by NMR and IR spectroscopy. ESTCPTA was labeled with Tc-99m and radio thin layer chromatography (RTLC) and radio-paper electrophoresis were used to determine the radiochemical yields. Specific activity was approximately 23.7 GBq/mmol and the labeling yield was over 95%. The biodistribution studies were performed on female Albino Wistar rats. The rats were sacricified by ether narcotization at certain time intervals and the activity of the organs was counted by a gamma counter. The activity per gram tissue was calculated and time activity curves were generated.en_US
dc.identifier.doi10.1023/A:1014898628890
dc.identifier.endpage479en_US
dc.identifier.issn0236-5731
dc.identifier.issn0236-5731en_US
dc.identifier.issue3en_US
dc.identifier.startpage473en_US
dc.identifier.urihttps://doi.org/10.1023/A:1014898628890
dc.identifier.urihttps://hdl.handle.net/11454/35448
dc.identifier.volume251en_US
dc.identifier.wosWOS:000174851200023en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherKluwer Academic Publen_US
dc.relation.ispartofJournal of Radioanalytical and Nuclear Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleAn oestrogen-derivative labeled with Tc-99m and its radiopharmaceutical potentialen_US
dc.typeArticleen_US

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