Effects of quercetin induced cell death on a novel gene "URG4/URGCP" expression in leukemia cells

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dc.contributor.authorDodurga Y.
dc.contributor.authorAvci C.B.
dc.contributor.authorSatiroglu-Tufan L.N.
dc.contributor.authorSusluer S.Y.
dc.contributor.authorSigva O.D.Z.
dc.contributor.authorSaydam, G..
dc.contributor.authorGunduz C.
dc.date.accessioned2019-10-26T21:53:29Z
dc.date.available2019-10-26T21:53:29Z
dc.date.issued2012
dc.departmentEge Üniversitesien_US
dc.description.abstractThe present study aimed to investigate anti-proliferative and apoptotic effects of quercetin on human leukemia cells and effects of quercetin-induced cell death on a novel gene Up-regulated gene 4/upregulator of cell proliferation (URG4/URGCP), in leukemia cells. URG4/URGCP expression is determined by using RT-PCR. IC 50 of quercetin was determined as 25 microM in CCRF-CEM, HL-60 and K562 cells. In IC 50 dose group, URG4/URGCP expression was decreased 99% in HL-60 cells, 90% in CCRF-CEM cells, and 52% (24 hour) - 99% (72 hour) in K-562 cells. URG4/URGCP may play important roles in the development of leukemia, and might be a useful molecular marker for predicting the prognosis of leukemia via quercetin treatment. © 2012 Dodurga Y, et al.en_US
dc.identifier.doi10.4172/1948-5956.1000102
dc.identifier.endpage9en_US
dc.identifier.issn1948-5956
dc.identifier.issn1948-5956en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage6en_US
dc.identifier.urihttps://doi.org/10.4172/1948-5956.1000102
dc.identifier.urihttps://hdl.handle.net/11454/18892
dc.identifier.volume4en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Cancer Science and Therapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLeukemia cellsen_US
dc.subjectQuercetinen_US
dc.subjectUrg4/urgcpen_US
dc.titleEffects of quercetin induced cell death on a novel gene "URG4/URGCP" expression in leukemia cellsen_US
dc.typeArticleen_US

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