The Effects of Arolycoricidine and Narciprimine on Tumor Cell Killing and Topoisomerase Activity

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dc.contributor.authorSarikaya, Buket Bozkurt
dc.contributor.authorZencir, Sevil
dc.contributor.authorSomer, Nehir Unver
dc.contributor.authorKaya, Gulen Irem
dc.contributor.authorOnur, Mustafa Ali
dc.contributor.authorBastida, Jaume
dc.contributor.authorBerenyi, Agnes
dc.contributor.authorZupko, Istvan
dc.contributor.authorTopcu, Zeki
dc.date.accessioned2019-10-27T21:33:58Z
dc.date.available2019-10-27T21:33:58Z
dc.date.issued2012
dc.departmentEge Üniversitesien_US
dc.description.abstractIn this study, narciprimine and arolycoricidine were isolated from G. rizehensis Stern (Amaryllidaceae). The structures of the alkaloids were elucidated by spectroscopic methods (1D NMR, EI-MS). Due to the previous reports on anti-cancer activity of this group of alkaloids, we investigated their effects on DNA topoisomerase reactions, which are known as the cellular targets of a number of chemotherapeutical drugs. The results revealed that arolycoricidine and narciprimine were effective in both type I and type II DNA topoisomerase reactions in a dose-dependent manner. Topoisomerase-interfering ability of these alkaloids partially correlated with cytostaticity assays, using HeLa (cervix adenocarcinoma), MCF7 (breast adenocarcinoma) and A431 (skin epidermoid carcinoma) cells. Our results are discussed in relation to the potential significance of these alkaloids in the course of drug-development studies.en_US
dc.description.sponsorshipTUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [TBAG108T548, TBAG-104T272]; EBILTEMEge University [2007/BIL/007]; TUBITAK-BIDEB research fellowshipTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK)en_US
dc.description.sponsorshipThis study was partially supported by the projects of TUBITAK (TBAG108T548, TBAG-104T272) and EBILTEM (2007/BIL/007), and one of the authors B. B. Sarikaya was a recipient of TUBITAK-BIDEB research fellowship.en_US
dc.identifier.endpage385en_US
dc.identifier.issn1307-6167
dc.identifier.issn1307-6167en_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage381en_US
dc.identifier.urihttps://hdl.handle.net/11454/45499
dc.identifier.volume6en_US
dc.identifier.wosWOS:000307955600009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAcg Publicationsen_US
dc.relation.ispartofRecords of Natural Productsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectArolycoricidineen_US
dc.subjectNarciprimineen_US
dc.subjectGalanthus rizehensisen_US
dc.subjectDNA Topoisomerasesen_US
dc.subjectCytostaticityen_US
dc.titleThe Effects of Arolycoricidine and Narciprimine on Tumor Cell Killing and Topoisomerase Activityen_US
dc.typeArticleen_US

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