Evaluation of the efficacy of Tc-99m-labeled ascorbic acid on common cold-cough drugs in rats

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dc.contributor.authorLambrecht, Fatma Yurt
dc.contributor.authorKayaalp, Erhan
dc.contributor.authorUnak, Perihan
dc.contributor.authorEnginar, Hueseyin
dc.contributor.authorMuftuler, F. Zuemruet Biber
dc.contributor.authorMedine, E. Ilker
dc.contributor.authorCetinkaya, Berkan
dc.date.accessioned2019-10-27T19:58:53Z
dc.date.available2019-10-27T19:58:53Z
dc.date.issued2007
dc.departmentEge Üniversitesien_US
dc.description.abstractMultiple-drug therapy is common in current clinical practice. Because of this, people have been ready to embrace simplistic approaches to cold treatment, such as vitamin C and zinc. Ascorbic acid (vitamin C) is mostly administrated together with cough-cold drugs. The aim of this study was to investigate the effect of cough-cold drugs on the uptake of ascorbic acid using Tc-99m-ascorbic acid (Tc-99m-AA) in male albino Wistar rats. Ascorbic acid was labeled with Tc-99m and the distribution of Tc-99m-AA was investigated. The uptake of Tc-99m-AA was evaluated when administrated alone (group I), with chlorpheniramine maleate (CPR) (group II), with phenylpropanolamine hydrochloride (PPA) (group III), and with acetaminophen (APAP) (group IV). In some organs (apart from kidneys, intestinal system, and stomach) the uptake of Tc-99m-AA was not significantly affected by the administration of Tc-99m with CPR or Tc-99m with APAP at 120 min. On the other hand, there was significant difference in the uptake of Tc-99m-AA between groups I and III. The administration of Tc-99m-AA with PPA in rats caused an increase of the uptake of Tc-99m-AA at 120 min in the investigated organs compared to the administration of Tc-99m-AA alone. The present data show that vitamin C might be more effective for the treatment of common cold when coad-ministered with PPA compared to with CPR, with APAP, or alone.en_US
dc.identifier.doi10.1007/s00044-007-9083-y
dc.identifier.endpage435en_US
dc.identifier.issn1054-2523
dc.identifier.issn1054-2523en_US
dc.identifier.issue07.Sepen_US
dc.identifier.startpage427en_US
dc.identifier.urihttps://doi.org/10.1007/s00044-007-9083-y
dc.identifier.urihttps://hdl.handle.net/11454/41122
dc.identifier.volume16en_US
dc.identifier.wosWOS:000254404800011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherSpringer Birkhauseren_US
dc.relation.ispartofMedicinal Chemistry Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectascorbic acid (AA)en_US
dc.subjectChlorpheniramine maleate (CPR)en_US
dc.subjectPhenylpropanolamine hydrochloride (PPA)en_US
dc.subjectAcetaminophen (APAP)en_US
dc.subjectTc-99m-ascorbic aciden_US
dc.titleEvaluation of the efficacy of Tc-99m-labeled ascorbic acid on common cold-cough drugs in ratsen_US
dc.typeArticleen_US

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