Male Individualization Based on Y-Chromosomal Short Tandem Repeats: A Comparative Information Theoretical Analysis of 16 Y-STR Loci in Central Anatolia and Iraqi Populations

Basit Öğe Kaydı
dc.contributor.authorIsir, Aysun Baransel
dc.contributor.authorOzkorkmaz, Abdulmuttalip
dc.contributor.authorBaransel, Cesur
dc.contributor.authorOzkorkmaz, Ebru Gokalp
dc.contributor.authorPehlivan, Sacide
dc.date.accessioned2019-10-27T22:58:56Z
dc.date.available2019-10-27T22:58:56Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractThe aim of this study is to investigate the discrimination capacity of 16 Y-Chromosomal Short Tandem Repeat markers (Y-STRs) based on their joint entropy for the purpose of male individualization on samples taken from Central Anatolia and Iraqi Populations. The Y-chromosome polymorphism of sixteen STR loci (DYS19, DYS385a/b, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS437, DYS438, DYS439, DYS448, DYS456, DYS458, DYS635, Y-GATA H4) were studied. Genomic DNA was extracted from buccal swabs using the QIAamp Mini kit and was co-amplified by using Applied Biosystems AmpFISTR (R) Yfiler (TM) PCR Amplification Kit. The Iraqi data set was readily available in the literature which is based on blood samples randomly collected from 100 healthy unrelated males living in middle or south of Iraq. The researchers observed 106 unique haplotypes in Central Anatolia data set. The genetic diversity values across the 16 Y-STR loci ranged from 0.564 (DYS391) to 0.876 (DYS385a/b). The complete male individualization with only 16 Y-STR markers in a genetically diverse local population is possible. In this study, haplotype diversity was 1.0 and discrimination capacity was 100 percent. The high discrimination capacity of the 16 Y-STR markers makes them valuable for male individualization for forensic purposes in Central Anatolia Region of Turkey. The researchers also show that, the pointwise mutual information and the joint entropy between allele pairs measure the discrimination power of markers more accurately than individual genetic diversity values and provide a better insight into the interaction between the genetic profile of the population and the given Y-STR marker set.en_US
dc.description.sponsorshipUniversity of Gaziantep Research FundGaziantep University [TF.08.19]en_US
dc.description.sponsorshipThis study is financially supported by University of Gaziantep Research Fund (TF.08.19). The Y-STR data that appears in this manuscript were presented as a poster at 4th Mediterranean Academy of Forensic Sciences Meeting held in Antalya, Turkey from 14 to 18 October 2009.en_US
dc.identifier.endpage171en_US
dc.identifier.issn0972-3757
dc.identifier.issn0972-3757en_US
dc.identifier.issue4en_US
dc.identifier.startpage157en_US
dc.identifier.urihttps://hdl.handle.net/11454/51681
dc.identifier.volume15en_US
dc.identifier.wosWOS:000371185600001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherKamla-Raj Enterprisesen_US
dc.relation.ispartofInternational Journal of Human Geneticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCentral Anatolia and Iraqi Populationsen_US
dc.subjectEntropyen_US
dc.subjectPointwise Mutual Informationen_US
dc.subjectPopulation Geneticsen_US
dc.subjectY-STR Polymorphismsen_US
dc.titleMale Individualization Based on Y-Chromosomal Short Tandem Repeats: A Comparative Information Theoretical Analysis of 16 Y-STR Loci in Central Anatolia and Iraqi Populationsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu