Sustained-release verapamil and trandolapril, alone and in combination, in the treatment of obese hypertensive patients: A double-blind pilot study

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dc.contributor.authorNalbantgil, I
dc.contributor.authorOnder, R
dc.contributor.authorNalbantgil, S
dc.date.accessioned2019-10-27T11:54:46Z
dc.date.available2019-10-27T11:54:46Z
dc.date.issued1996
dc.departmentEge Üniversitesien_US
dc.description.abstractThe purpose of this pilot study was to compare the ability of sustained-release verapamil (verapamil SR) and trandolapril, both alone and combined in half doses, to reduce blood pressure in obese patients with mild-to-moderate essential hypertension. Twenty patients (13 men and 7 women) took part in the study. Ten (group A) received verapamil SR 240 mg/d, and 10 (group B) received trandolapril 2 mg/d for 6 weeks. All patients were then given both drugs in half-doses for 6 weeks. After combination therapy, group B received verapamil SR 240 mg/d, and group A received trandolapril 2 mg/d for 6 weeks. When verapamil and trandolapril were used alone, systolic and diastolic blood pressures decreased significantly in each group. However, systolic and diastolic blood pressures fell further when combination therapy was used and rose slightly when the treatment was changed again to single-drug therapy. Side effects were fewer during the combination therapy. Thus the combination of half doses of verapamil SR and trandolapril was more effective in reducing blood pressure in obese patients with mild-to-moderate essential hypertension than a full dose of either drug given alone.en_US
dc.identifier.doi10.1016/S0011-393X(96)80117-2
dc.identifier.endpage997en_US
dc.identifier.issn0011-393X
dc.identifier.issn0011-393Xen_US
dc.identifier.issue12en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage990en_US
dc.identifier.urihttps://doi.org/10.1016/S0011-393X(96)80117-2
dc.identifier.urihttps://hdl.handle.net/11454/35063
dc.identifier.volume57en_US
dc.identifier.wosWOS:A1996WB93000010en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherExcerpta Medica Incen_US
dc.relation.ispartofCurrent Therapeutic Research-Clinical and Experimentalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleSustained-release verapamil and trandolapril, alone and in combination, in the treatment of obese hypertensive patients: A double-blind pilot studyen_US
dc.typeArticleen_US

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