PLGA encapsulation effect on Bioquin-HMPAO: radiolabeling and in vitro behaviour on brain and lung cancer cells

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dc.contributor.authorKilcar, Ayfer Yurt
dc.contributor.authorMuftuler, F. Zumrut Biber
dc.contributor.authorMedine, E. Ilker
dc.contributor.authorTekin, Volkan
dc.date.accessioned2019-10-27T11:26:17Z
dc.date.available2019-10-27T11:26:17Z
dc.date.issued2016
dc.departmentEge Üniversitesien_US
dc.description.abstractBioquin-HMPAO (BH) was previously investigated as a novel brain imaging agent by in vivo biodistribution studies. Present studies are carried out to explore radiolabeling and in vitro behaviour evaluation of poly (lactic-co-glycolic acid) (PLGA) encapsulated BH nanocapsules (BH-PLGA NCs). BH-PLGA NCs were characterized utilizing dynamic light scattering and scanning electron microscope. Encapsulation effect on radiolabeling with Tc-99m was examined by stability and lipophilicity studies and effect on in vitro behaviour of Tc-99m-BH was evaluated by incorporation studies on DAOY, U87-MG and A549 cells. It is observed that PLGA encapsulation has a positive and reinforcement effect.en_US
dc.description.sponsorshipEge University Research FundEge University [2011 NBE 003]en_US
dc.description.sponsorshipCurrent work is supported by Ege University Research Fund (contract no 2011 NBE 003). The authors thank to Cansu Uzaras and Cigdem Ichedef for the technical assistance during the assays.en_US
dc.identifier.doi10.1007/s10967-016-4746-0
dc.identifier.endpage164en_US
dc.identifier.issn0236-5731
dc.identifier.issn1588-2780
dc.identifier.issn0236-5731en_US
dc.identifier.issn1588-2780en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage155en_US
dc.identifier.urihttps://doi.org/10.1007/s10967-016-4746-0
dc.identifier.urihttps://hdl.handle.net/11454/33475
dc.identifier.volume310en_US
dc.identifier.wosWOS:000383579900016en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Radioanalytical and Nuclear Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBioquin-HMPAOen_US
dc.subjectPLGA encapsulationen_US
dc.subjectRadiolabelingen_US
dc.subjectTc-99men_US
dc.subjectBrain cancer cellsen_US
dc.subjectIncorporationen_US
dc.titlePLGA encapsulation effect on Bioquin-HMPAO: radiolabeling and in vitro behaviour on brain and lung cancer cellsen_US
dc.typeArticleen_US

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