The relationship between nutritional status and Fetuin-A in Inflammatory Bowel Disease patients

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dc.contributor.authorBarutcuoglu, Burcu
dc.contributor.authorUnal, Nalan Gulsen
dc.contributor.authorAk, Gunes
dc.contributor.authorParildar, Zuhal
dc.contributor.authorOruc, Nevin
dc.contributor.authorOzutemiz, Ahmet Omer
dc.date.accessioned2021-05-03T20:27:38Z
dc.date.available2021-05-03T20:27:38Z
dc.date.issued2021
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: To investigate the relationship between fetuin-A and nutritional index parameters body mass index (BMI), fat mass (FM), fat free mass (FFM) and mini nutritional assessment (MNA (R)) in inflammatory bowel disease (IBD) patients. Design: Randomized, prospective study Setting: Department of Clinical Biochemistry and Gastroenterolgy, Medical School, Ege University, Izmir, Turkey Subjects: Seventy-six consecutive IBD out-patients and 24 healthy volunteers were enrolled in this study. IBD patients were grouped into: 1. BMI<18.5 kg/m(2); 2. BMI=18.5-24.9 kg/m(2); and 3. BMI >= 25 kg/m(2) and according to MNA (R) score as: 1. MNA (R) <17, 2. MNA (R)=17.5-23.5 and 3. MNA (R)>= 24. Interventions: Demographical data and nutritional index parameters (BMI, FM, FFM) were evaluated. MNA was assessed by a questionnaire. Main outcome measures: Fasting serum levels of albumin, glucose, total cholesterol, triglyceride, C-reactive protein (CRP), vitamin B12, folic acid, ferritin, fetuin-A, hemoglobin and white blood cell count were measured. Results: The level of CRP was significantly higher and fetuin-A was significantly lower (both P<.001) in IBD patients than in healthy subjects. Age (P<.001), MNA (R) total score (P=.001), FM (P<.001), FFM (P=.003) and fetuin-A (P=.012) were significantly different between the BMI groups. There was a significant difference in BMI (P<.001), FM (P<.001), FFM (P<.001), levels of Fetuin-A (P=.030) and CRP (P=.030) between MNA (R) groups. There was a weak correlation between fetuin-A and BMI (r=0.249,P=.030). Conclusion: in this study, fetuin-A, a negative acute phase protein is shown to be related to BMI in IBD patients. Serum fetuin-A levels were the lowest both in MNA<17 and BMI<18.5 kg/m(2), which showed us that it can predict nutritional status in IBD patients.en_US
dc.description.sponsorshipEge University Research Projects, Izmir, TurkeyEge Universityen_US
dc.description.sponsorshipThis study was supported by the Ege University Research Projects, Izmir, Turkey.en_US
dc.identifier.endpage80en_US
dc.identifier.issn0023-5776
dc.identifier.issn0023-5776en_US
dc.identifier.issue1en_US
dc.identifier.startpage74en_US
dc.identifier.urihttps://hdl.handle.net/11454/69597
dc.identifier.volume53en_US
dc.identifier.wosWOS:000628754900013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherKuwait Medical Assocen_US
dc.relation.ispartofKuwait Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectchronic inflammationen_US
dc.subjectfetuin-Aen_US
dc.subjectinflammatory bowel diseaseen_US
dc.subjectmalnutritionen_US
dc.titleThe relationship between nutritional status and Fetuin-A in Inflammatory Bowel Disease patientsen_US
dc.typeArticleen_US

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