Colistin and acute renal failure: A centre's experience

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dc.contributor.authorHür E.
dc.contributor.authorÇetintürk A.
dc.contributor.authorEmino?lu V.
dc.contributor.authorSungur M.
dc.contributor.authorTavşan Ö.
dc.contributor.authorPişkinpaşa S.V.
dc.contributor.authorSevercan E.
dc.contributor.authorKaraca N.
dc.contributor.authorDuman S.
dc.date.accessioned2019-10-26T21:31:59Z
dc.date.available2019-10-26T21:31:59Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractOBJECTIVE: Colistin is a polymyxin antibiotic with a polypeptide structure and is effective against gram-negative bacilli. Although its use had decreased due to its side effects, it has increased again in recent years, especially for multi-drug resistant Pseudomonas aeruginosa, Klebsiella pneumoniae, Acinetobacter and Enterobacteriaceae. In the present study, patients that received colistin at one center were retrospectively analysed in terms of nephrotoxicity.MATERIAL and METHODS: Patients hospitalized and treated with colistin in the intensive care unit between January 2012 and August 2013 were analyzed. Demographic data; biochemical tests at baseline, daily during hospitalization and after discharge; and the initial, maintenance and total doses of colistin were evaluated.RESULTS: The mean age was 62±13 (31-86) years for the 27 patients with 17 (63%) males that were followed-up for an average duration of 63±89 days. During follow-up, 18 patients (66.7%) developed acute renal failure (ARF) and 17 (63%) of died. There were 12 (66.7%) mortalities in the ARF group and 5 (55%) in the group without ARF ( p> 0.05). The total colistin dose and leukocyte count were higher in the ARF group with 3.75±2.34 g and 12.04±5.05/mm3 than the non-ARF group at 3.32±1.86 g and 7.60±3.7/mm3 but did not reach statistical significance.CONCLU SION: ARF increases the mortality in ICU patients. Although colistin is an effective therapeutic agent used for resistant infections, we have to avoid higher doses due to its potential side effect of ARF.en_US
dc.identifier.doi10.5262/tndt.2014.1003.04
dc.identifier.endpage201en_US
dc.identifier.issn1300-7718
dc.identifier.issn1300-7718en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage196en_US
dc.identifier.urihttps://doi.org/10.5262/tndt.2014.1003.04
dc.identifier.urihttps://hdl.handle.net/11454/17725
dc.identifier.volume23en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTurkish Society of Nephrologyen_US
dc.relation.ispartofTurkish Nephrology, Dialysis and Transplantation Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute renal failureen_US
dc.subjectColistinen_US
dc.subjectNephrotoxicityen_US
dc.titleColistin and acute renal failure: A centre's experienceen_US
dc.typeArticleen_US

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