An immunoelectrochemical platform for the biosensing of 'Cocaine use'

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dc.contributor.authorSengel, Tulay Yilmaz
dc.contributor.authorGuler, Emine
dc.contributor.authorGumus, Z. Pinar
dc.contributor.authorAldemir, Ebru
dc.contributor.authorCoskunol, Hakan
dc.contributor.authorAkbulut, Huseyin
dc.contributor.authorColak, Demet Goen
dc.contributor.authorCianga, Ioan
dc.contributor.authorYamada, Shuhei
dc.contributor.authorTimur, Suna
dc.contributor.authorEndo, Takeshi
dc.contributor.authorYagci, Yusuf
dc.date.accessioned2019-10-27T11:07:21Z
dc.date.available2019-10-27T11:07:21Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractIn the present work, we demonstrate a novel surface design by combination of benzoylecgonine (BE) antibody and poly-L-phenylalanine bearing electroactive macromonomer (EDOT-BTDA-PPhe). This system served as an electro-immunosensor platform for the analysis of cocaine use by detecting both BE and cocaine. To construct the immunosensor, a glassy carbon electrode was covered with EDOT-BTDA-PPhe. Subsequently, BE antibody was immobilized on the polypeptide chains. The surface modifications were confirmed by electrochemical techniques. The immunosensor was used for the electrochemical detection of BE and cocaine as evidence of drug addiction. For both analytes, linearity was obtained between 0.5-25 mu M. Finally, the proposed system was successfully employed for the analysis of synthetic biological fluids. (C) 2017 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipIndustrial Thesis Support Program (SAN-TEZ) of Republic of TurkeyMinistry of Science, Industry & Technology - Turkey; Republic of Turkey, Ministry of DevelopmentTurkiye Cumhuriyeti Kalkinma Bakanligi [20161(121190]; Ege University Research Fund through BAP project [16-FEN-004]; Istanbul Technical University Research Fund; TUBITAI; Ministry of Science, Industry and Technology [0620.STZ.2014]; Likrom Company (Turkey)en_US
dc.description.sponsorshipThis work was supported by Industrial Thesis Support Program (SAN-TEZ) of Republic of Turkey, Ministry of Science, Industry and Technology (Project Grant No: 0620.STZ.2014) and Republic of Turkey, Ministry of Development (Project Grant No: 20161(121190). This work was also partially supported by Ege University Research Fund through BAP project (Project No: 16-FEN-004) and Istanbul Technical University Research Fund. Likrom Company (Turkey) was acknowledged for their support to the chromatographic analyses. One of the authors (I.C) thanks to TUBITAI for the financial support by means of "Fellowships For Visiting Scientists and Scientists On Sabbatical Leave" programme.en_US
dc.identifier.doi10.1016/j.snb.2017.02.087
dc.identifier.endpage318en_US
dc.identifier.issn0925-4005
dc.identifier.issn0925-4005en_US
dc.identifier.startpage310en_US
dc.identifier.urihttps://doi.org/10.1016/j.snb.2017.02.087
dc.identifier.urihttps://hdl.handle.net/11454/32014
dc.identifier.volume246en_US
dc.identifier.wosWOS:000400803700039en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherElsevier Science Saen_US
dc.relation.ispartofSensors and Actuators B-Chemicalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSurface modificationen_US
dc.subjectImmunosensoren_US
dc.subjectBiochemical screening toolen_US
dc.subjectAbused drug detectionen_US
dc.subjectCocaineen_US
dc.titleAn immunoelectrochemical platform for the biosensing of 'Cocaine use'en_US
dc.typeArticleen_US

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