Functional poly(p-phenylene)s as targeting and drug carrier materials

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dc.contributor.authorGuler, Bahar
dc.contributor.authorAkbulut, Huseyin
dc.contributor.authorGeyik, Caner
dc.contributor.authorBarlas, F. Baris
dc.contributor.authorDemirkol, Dilek Odaci
dc.contributor.authorCoskunol, Hakan
dc.contributor.authorTimur, Suna
dc.contributor.authorYagci, Yusuf
dc.date.accessioned2019-10-27T22:58:38Z
dc.date.available2019-10-27T22:58:38Z
dc.date.issued2016
dc.departmentEge Üniversitesien_US
dc.description.abstractPolymers have a substantial attention in drug delivery systems owing to the diverse intrinsic advantages. It is important to carry the drug to the target site and release to exert its effects. Herein, poly(p-phenylene)s with amino and poly(ethylene glycol) substituents (PPP-NH2-g-PEG) were used as a carrier for doxorubicin (DOX), an anticancer drug, and haloperidol, a sigma receptor targeting ligand. Both human cervix adenocarcinoma cell line (HeLa) and human keratinocyte cell line (HaCaT) having different Sigma receptor 1 (SigmaR1) expression levels were compared. HeLa was found to express twofold SigmaR1 compared to HaCaT cells. Cell imaging studies showed that, DOX cell uptake was higher in HeLa cells when targeted with haloperidol. [GRAPHICS] .en_US
dc.description.sponsorshipEge UniversityEge University; Aliye USTER Foundation; Istanbul Technical University, Research Funden_US
dc.description.sponsorshipEge University, Aliye USTER Foundation, and Istanbul Technical University, Research Fund, are acknowledged for financial support.en_US
dc.identifier.doi10.1080/00914037.2016.1157797
dc.identifier.endpage659en_US
dc.identifier.issn0091-4037
dc.identifier.issn1563-535X
dc.identifier.issn0091-4037en_US
dc.identifier.issn1563-535Xen_US
dc.identifier.issue13en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage653en_US
dc.identifier.urihttps://doi.org/10.1080/00914037.2016.1157797
dc.identifier.urihttps://hdl.handle.net/11454/51604
dc.identifier.volume65en_US
dc.identifier.wosWOS:000375958100002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Asen_US
dc.relation.ispartofInternational Journal of Polymeric Materials and Polymeric Biomaterialsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBioconjugationen_US
dc.subjectdrug deliveryen_US
dc.subjectgraft copolymeren_US
dc.subjectpoly(p-phenylene)sen_US
dc.subjectsigma receptoren_US
dc.titleFunctional poly(p-phenylene)s as targeting and drug carrier materialsen_US
dc.typeArticleen_US

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