Antileishmanial Activity of Selected Turkish Medicinal Plants

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dc.contributor.authorOzbilgin, Ahmet
dc.contributor.authorDurmuskahya, Cenk
dc.contributor.authorKayalar, Husniye
dc.contributor.authorErtabaklar, Hatice
dc.contributor.authorGunduz, Cumhur
dc.contributor.authorUral, Ipek Ostan
dc.contributor.authorZeyrek, Fadile
dc.contributor.authorKurt, Ozgur
dc.contributor.authorCavus, Ibrahim
dc.contributor.authorBalcioglu, Cuneyt
dc.contributor.authorToz, Seray Ozensoy
dc.contributor.authorOzbel, Yusuf
dc.date.accessioned2019-10-27T22:12:23Z
dc.date.available2019-10-27T22:12:23Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractPurpose: To determine the in vitro and in vivo anti-leishmanial activities of extracts obtained from Centaurea calolepis, Phlomis lycia, Eryngium thorifolium, Origanum sipyleum and Galium incanum ssp. centrale. Methods: To estimate the cytotoxicity of plant extracts, WST-1 assay was used. Parasite inhibition in the presence of plant extracts (25 - 500 mu g/ml) in comparision with control group and reference group (glucantime, 25 mu g/ml) at 12 - 72 h were determined in vitro on L. tropica promastigotes. The in vivo leishmanicidal activity of the extracts was evaluated against L. tropica-infected mice with glucantime as reference drug. Results: The chloroform extract of Galium incanum ssp. centrale showed the highest cytotoxicity with IC50 value of 0.0316 +/- 0.005 mu g/ml. In vitro parasite inhibition by the plant extracts ranged between 16.7 +/- 0.01 % and 100 +/- 0.00 % at 25 mu g/ml concentration. The methanol extract of Eryngium thorifolium possessed the highest activity on promastigotes of L. tropica with 100 % inhibition at 25 mu g/ml. The water and chloroform extracts of C. calolepis and water and methanol extracts of E. thorifolium at a dose of 100 mg/kg reduced parasitaemia in L. tropica infected mice. Conclusion: Parasite viability results suggest that the methanol extract of Eryngium thorifolium, regarded as non-cytotoxic, is a promising candidate drug for treating L. tropica infection.en_US
dc.description.sponsorshipTUBITAK (The Scientific and Technological Research Council of Turkey)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [110S289]en_US
dc.description.sponsorshipThis study received financial support from TUBITAK (The Scientific and Technological Research Council of Turkey) - grant no. 110S289.en_US
dc.identifier.doi10.4314/tjpr.v13i12.15
dc.identifier.endpage2055en_US
dc.identifier.issn1596-5996
dc.identifier.issn1596-5996en_US
dc.identifier.issue12en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage2047en_US
dc.identifier.urihttps://doi.org/10.4314/tjpr.v13i12.15
dc.identifier.urihttps://hdl.handle.net/11454/49403
dc.identifier.volume13en_US
dc.identifier.wosWOS:000350412700015en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPharmacotherapy Groupen_US
dc.relation.ispartofTropical Journal of Pharmaceutical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLeishmaniasisen_US
dc.subjectLeishmania tropicaen_US
dc.subjectEryngium thorifoliumen_US
dc.subjectPromastigoteen_US
dc.subjectWI-38 Human fibroblastsen_US
dc.titleAntileishmanial Activity of Selected Turkish Medicinal Plantsen_US
dc.typeArticleen_US

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