The role of tumor microenvironment and self-organization in cancer progression: Key insights for therapeutic development

Basit Öğe Kaydı
dc.authorid0000-0001-7846-2908
dc.authorid0000-0001-8162-5325
dc.authorid0000-0003-3058-9971
dc.authorid0000-0001-5190-0349
dc.contributor.authorAsadi, Milad
dc.contributor.authorZafari, Venus
dc.contributor.authorSadeghi Mohammadi, Sanam
dc.contributor.authorShanehbandi, Dariush
dc.contributor.authorMert, Ufuk
dc.contributor.authorSoleimani, Zahra
dc.contributor.authorCaner, Ayse
dc.date.accessioned2025-02-21T13:06:25Z
dc.date.available2025-02-21T13:06:25Z
dc.date.issued2024
dc.departmentEge Üniversitesi, Sağlık Bilimleri Enstitüsü, Temel Onkoloji Ana Bilim Dalı
dc.description.abstractIntroduction: The tumor microenvironment (TME) plays a pivotal role in cancer progression, influencing tumor initiation, growth, invasion, metastasis, and response to therapies. This study explores the dynamic interactions within the TME, particularly focusing on selforganization-a process by which tumor cells and their microenvironment reciprocally shape one another, leading to cancer progression and resistance. Understanding these interactions can reveal new prognostic markers and therapeutic targets within the TME, such as extracellular matrix (ECM) components, immune cells, and cytokine signaling pathways. Methods: A comprehensive search method was employed to investigate the current academic literature on TME, particularly focusing on self-organization in the context of cancer progression and resistance across the PubMed, Google Scholar, and Science Direct databases. Results: Recent studies suggest that therapies that disrupt TME self-organization could improve patient outcomes by defeating drug resistance and increasing the effectiveness of conventional therapy. Additionally, this research highlights the essential of understanding the biophysical properties of the TME, like cytoskeletal alterations, in the development of more effective malignancy therapy. Conclusion: This review indicated that targeting the ECM and immune cells within the TME can improve therapy effectiveness. Also, by focusing on TME self-organization, we can recognize new therapeutic plans to defeat drug resistance.
dc.identifier.citationAsadi, M., Zafari, V., Sadeghi-Mohammadi, S., Shanehbandi, D., Mert, U., Soleimani, Z., Caner, A., & Zarredar, H. (2024). The role of tumor microenvironment and self-organization in cancer progression: Key insights for therapeutic development. Bioimpacts.
dc.identifier.doi10.34172/bi.30713
dc.identifier.endpage15
dc.identifier.issn2228-5652
dc.identifier.issueDec
dc.identifier.scopus2-s2.0-85217889232
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.34172/bi.30713
dc.identifier.urihttps://hdl.handle.net/11454/116149
dc.identifier.volume15
dc.identifier.wosWOS:001378856300001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.institutionauthorAsadi, Milad
dc.institutionauthorZafari, Venus
dc.institutionauthorMert, Ufuk
dc.institutionauthorCaner, Ayse
dc.institutionauthorid0000-0001-7846-2908
dc.institutionauthorid0000-0001-8162-5325
dc.institutionauthorid0000-0003-3058-9971
dc.language.isoen
dc.publisherTabriz University of Medical Sciences and Health Services
dc.relation.ispartofBioimpacts
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTumor micro
dc.subjectenvironment
dc.subjectSelf-organization
dc.subjectExtracellular matrix
dc.subjectMetastasis
dc.subjectInvasion
dc.titleThe role of tumor microenvironment and self-organization in cancer progression: Key insights for therapeutic development
dc.typeArticle

Dosyalar

Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.17 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu