Oxidative DNA Damage-Mediated Genomic Heterogeneity Is Regulated by NKX3.1 in Prostate Cancer

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dc.contributor.authorDebelec-Butuner, Bilge
dc.contributor.authorBostanci, Aykut
dc.contributor.authorOzcan, Filiz
dc.contributor.authorSingin, Oznur
dc.contributor.authorKaramil, Selda
dc.contributor.authorAslan, Mutay
dc.contributor.authorRoggenbuck, Dirk
dc.contributor.authorKorkmaz, Kemal Sami
dc.date.accessioned2019-10-27T09:46:16Z
dc.date.available2019-10-27T09:46:16Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.description.abstractThe 8-hydroxy-2 '-deoxyguanosine (8-OHdG) damages are base damages induced by reactive oxygen species. We aimed to investigate the role of Androgen Receptor and NKX3.1 in 8-OHdG formation and repair activation by quantitating the DNA damage using Aklides.NUK system. The data demonstrated that the loss of NKX3.1 resulted in increased oxidative DNA damage and its overexpression contributes to the removal of menadione-induced 8-OHdG damage even under oxidative stress conditions. Moreover, 8-oxoguanine DNA glycosylase-1 (OGG1) expression level positively correlates to NKX3.1 expression. Also in this study, first time a reliable cell-based quantitation method for 8-OHdG damages is reported and used for data collection.en_US
dc.description.sponsorshipTurkish Scientific and Technology Research Council (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [113S044]; COST program EU-ROS [BM1203]en_US
dc.description.sponsorshipThis research is supported by a grant [113S044] from Turkish Scientific and Technology Research Council (TUBITAK) to KSK, and COST program EU-ROS, [BM1203] for mobility and data sharing.en_US
dc.identifier.doi10.1080/07357907.2019.1576192
dc.identifier.endpage126en_US
dc.identifier.issn0735-7907
dc.identifier.issn1532-4192
dc.identifier.issn0735-7907en_US
dc.identifier.issn1532-4192en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage113en_US
dc.identifier.urihttps://doi.org/10.1080/07357907.2019.1576192
dc.identifier.urihttps://hdl.handle.net/11454/29252
dc.identifier.volume37en_US
dc.identifier.wosWOS:000462343500006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofCancer Investigationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject8-OHdGen_US
dc.subjectNKX3en_US
dc.subject1en_US
dc.subjectAndrogen receptoren_US
dc.subjectAklidesen_US
dc.titleOxidative DNA Damage-Mediated Genomic Heterogeneity Is Regulated by NKX3.1 in Prostate Canceren_US
dc.typeArticleen_US

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