Caffeic acid phenethyl ester (CAPE) Chitosan capped ZnO nanoparticles: Preparation, characterization, and its potential for the treatment of prostate cancer

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dc.contributor.authorInce, Iskender
dc.contributor.authorYildirim, Yeliz
dc.contributor.authorGoker, Erdem
dc.contributor.authorGuler, Gunnur
dc.contributor.authorSaltan, Fehmi
dc.contributor.authorAcar, Riza
dc.contributor.authorGumustas, Baris
dc.date.accessioned2024-08-31T07:47:31Z
dc.date.available2024-08-31T07:47:31Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractThe synthesis of zinc oxide nanoparticles/chitosan (ZnONPs/CS) formulation loaded with Caffeic acid phenethyl ester (CAPE) was performed to evaluate its prostate cancer treatment efficiency within the scope of this research. It has been hypothesized that a dual active materials delivery system containing ZnO and CAPE loaded Chitosan (CS) nanoparticles has better bioavailability compared to single one against to cancer cells. ZnONPs were synthesized between 45 and 60 nm particle sizes and then they were capped with CS biodegradable polymer prior to load with CAPE bioactive molecule. ZnONPs/CS-CAPE system was characterized by using Fourier Transform Infrared (FTIR) for structural elucidation, Scanning Electron Microscope (SEM) for particle size determination, High Performance Liquid Chromatography (HPLC) system for determination of CAPE amount. 131 I CAPE and 131 I ZnONPs/CS-CAPE labeled by the Iodogen method with 131 I were used in -vitro cell culture experiments. Cell viabilities (%) of CAPE and ZnONPs/CS-CAPE were examined using Cell Counting Kit -8 assay on PC -3 (human adenocarcinoma prostate), LnCaP (human carcinoma prostate), and RWPE-1 (human normal prostate). IC 50 values of ZnONPs /CS -CAPE on all cells were found 2 -fold lower than neat CAPE. Based on the FTIR data, the most significant spectral changes (lipid, protein, nucleic acids, glycogen) were monitored for the PC -3 and LnCaP cancer cells incubated with ZnONPs/CS-CAPE samples while being exposed to neat CAPE molecules caused small cellular changes when compared to RWPE-1 healthy cell lines.en_US
dc.identifier.doi10.1016/j.molstruc.2024.138562
dc.identifier.issn0022-2860
dc.identifier.issn1872-8014
dc.identifier.scopus2-s2.0-85193536008en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2024.138562
dc.identifier.urihttps://hdl.handle.net/11454/104452
dc.identifier.volume1312en_US
dc.identifier.wosWOS:001264183900003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Molecular Structureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240831_Uen_US
dc.subjectCaffeic Acid Phenethyl Esteren_US
dc.subjectZinc Oxide Nanoparticleen_US
dc.subjectChitosanen_US
dc.subjectProstate Cancer Treatmenten_US
dc.titleCaffeic acid phenethyl ester (CAPE) Chitosan capped ZnO nanoparticles: Preparation, characterization, and its potential for the treatment of prostate canceren_US
dc.typeArticleen_US

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