Clinical Features and Course in Pediatric Onset Multiple Sclerosis

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dc.contributor.authorEkmekci, Ozgul
dc.contributor.authorYuceyar, Nur
dc.contributor.authorKocaman Sagduyu, Ayse
dc.date.accessioned2019-10-27T21:33:48Z
dc.date.available2019-10-27T21:33:48Z
dc.date.issued2012
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: Multiple Sclerosis is uncommon in children and adolescents. Two to 5 % of all patients with MS have onset before age 16. Although the clinical profile of MS appears similar to adults some features may differ. The disease may lead to significant disability at a younger age. Our aim is to determine the clinical features and, disease course in pediatric onset multiple sclerosis. Methods: In this study, we evaluated 21 patients with pediatric onset (before age 18). The records of patients were reviewed retrospectively. The following variables were evaluated; sex, age at onset, presenting symptoms, disease course, relapse rate, immunomodulatory treatment. Results: Twenty one patients were included to study. The mean age at onset was 15.2 (ranged 8-17). The female/male ratio was 1.3. The median follow up period was 5 years. The major presenting symptoms were pyramidal (9 patients), brainstem (8 patients) and optic neuritis (4 patients). The initial disease course was relapsing remitting in 19 patients but in 3 patients, secondary progression was observed before age 30. Two patients were with clinically isolated syndrome. Nineteen patients were treated with immunomodulatory drugs. In 4 patients Mitoxantrone was used because of progressive course and relapses. Conclusion: The clinical presentation of multiple sclerosis with pediatric onset is usually benign but in the long term, patients with pediatric onset can become disabled at a younger age.en_US
dc.identifier.endpage809en_US
dc.identifier.issn1302-1664
dc.identifier.issn1302-1664en_US
dc.identifier.issue4en_US
dc.identifier.startpage804en_US
dc.identifier.urihttps://hdl.handle.net/11454/45414
dc.identifier.volume29en_US
dc.identifier.wosWOS:000312600000015en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherJournal Neurological Sciencesen_US
dc.relation.ispartofJournal of Neurological Sciences-Turkishen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMultiple sclerosisen_US
dc.subjectEarly onset multiple sclerosisen_US
dc.subjectPediatric onset multiple sclerosisen_US
dc.titleClinical Features and Course in Pediatric Onset Multiple Sclerosisen_US
dc.typeArticleen_US

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