Evaluation of the effects of bile on the arterial tonus in a rabbit model

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dc.contributor.authorTemiz G.
dc.contributor.authorMezili C.
dc.contributor.authorTiftikçioglu Y.Ö.
dc.contributor.authorŞirinoglu H.
dc.contributor.authorÇinar M.
dc.contributor.authorKismali E.
dc.contributor.authorNart D.
dc.contributor.authorGürler T.
dc.contributor.authorAlper M.
dc.date.accessioned2019-10-26T21:25:57Z
dc.date.available2019-10-26T21:25:57Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: Hepatic artery anastomosis is an essential part of live-donor liver transplantation, and during this anastomosis, an unusual contact between bile and vessel ends is observed. In this study, the effects of this nonphysiological contact in a rabbit model were evaluated. Methods: The study was designed in 2 steps - in vitro and in vivo. Three groups were established for the in vitro study. In the first group, vessels were incubated in Krebs solution with 5% bile for 1 minute. In the second group, vessels were kept in Krebs solution with 5% bile for 5 minutes. Vessels in the control group were kept in Krebs solution without bile. All groups were examined for responses to vasodilator and vasoconstrictor agents in organ bath system. The specimens were evaluated immunohistochemically and histopathologically. In the in vivo step, microvascular anastomosis was performed bilaterally. Right carotid artery was anastomosed during bile contamination as study group, and left carotid artery was anastomosed without bile contamination as control group. Blood flow indexes were measured. Results: The results of the in vitro study revealed decreased responses to contractile and relaxing agents in the first study group compared with that of the control group (P < 0.0001). There was no response obtained in the second study group. The Doppler ultrasound results revealed no difference between preoperative and postoperative flow indexes (P > 0.05). There was no postoperative spasm in the study group. However, there was significant vasospasm in the control group (P < 0.05). Conclusions: Vessels exposed to bile have decreased contractile and relaxing responses, and this effect increases with exposure duration. Copyright © 2015 The Authors.en_US
dc.identifier.doi10.1097/GOX.0000000000000546
dc.identifier.issn2169-7574
dc.identifier.issn2169-7574en_US
dc.identifier.issue11en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1097/GOX.0000000000000546
dc.identifier.urihttps://hdl.handle.net/11454/17304
dc.identifier.volume3en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherLippincott Williams and Wilkinsen_US
dc.relation.ispartofPlastic and Reconstructive Surgery - Global Openen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleEvaluation of the effects of bile on the arterial tonus in a rabbit modelen_US
dc.typeArticleen_US

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