Foreign-body reaction due to incorrect injections of allergen extracts containing aluminum hydroxide gel [Réactions à corps étranger à la suite de l'injection d'extraits allergéniques contenant de l'hydroxyde d'alumine]

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dc.contributor.authorGülbahar O.
dc.contributor.authorOzturk G.
dc.contributor.authorKazandi A.C.
dc.contributor.authorKokuludag A.
dc.date.accessioned2019-10-27T08:59:19Z
dc.date.available2019-10-27T08:59:19Z
dc.date.issued2005
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground. - Subcutaneous allergen immunotherapy is considered as effective and safe in allergic patients. Although mild local cutaneous reactions occur frequently, the development of persistent nodules at the injection site is a rare event. We describe a case with unusual persistent nodular reactions at the sites of previous immunizations incorrectly performed via the intradermal route. Case. - A 42-year-old female presented with multiple persistent lesions on both forearms that appeared after allergen immunotherapy. Immunotherapy with an aluminum hydroxide-adsorbed mite extract had been started 3:years earlier. Prescription of immunotherapy and injections of the extract were performed in a rural private medical facility, under the supervision of a physician with no special allergy training; injections had been given erroneously intradermally rather than subcutaneously. Physical examination revealed multiple reddish, indurated cutaneous nodules at the injection sites. The diagnosis of a foreign-body granulomatous reaction was confirmed by histological examination of the lesions. Conclusions. - Intradermal injections of aluminum hydroxide-containing allergen extracts should be strictly avoided. This case emphasizes published international recommendations according to which specific allergen immunotherapy should be prescribed only by allergy specialists in order to avoid unsuitable indications and methods that can sometimes result in serious side effects. © 2005 Elsevier SAS. All rights reserved.en_US
dc.identifier.doi10.1016/j.allerg.2005.02.017
dc.identifier.endpage331en_US
dc.identifier.issn0335-7457
dc.identifier.issn0335-7457en_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage328en_US
dc.identifier.urihttps://doi.org/10.1016/j.allerg.2005.02.017
dc.identifier.urihttps://hdl.handle.net/11454/27763
dc.identifier.volume45en_US
dc.indekslendigikaynakScopusen_US
dc.language.isofren_US
dc.relation.ispartofRevue Francaise d'Allergologie et d'Immunologie Cliniqueen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdverse effectsen_US
dc.subjectAllergen immunotherapyen_US
dc.subjectAluminum hydroxideen_US
dc.subjectForeign-body reactionen_US
dc.subjectGranulomasen_US
dc.titleForeign-body reaction due to incorrect injections of allergen extracts containing aluminum hydroxide gel [Réactions à corps étranger à la suite de l'injection d'extraits allergéniques contenant de l'hydroxyde d'alumine]en_US
dc.typeArticleen_US

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