Evaluation of filtering bleb function after trabeculectomy with mitomycin C using biomicroscopy, anterior segment optical coherence tomography and in vivo confocal microscopy

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dc.contributor.authorYılmaz S.G.
dc.contributor.authorDeğirmenci C.
dc.contributor.authorPalamar M.
dc.contributor.authorYağcı A.
dc.date.accessioned2019-10-26T21:24:05Z
dc.date.available2019-10-26T21:24:05Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractObjectives: To analyze and assess compatibility of trabeculectomy filtering bleb characteristics and appearances using biomicroscopy, anterior segment optical coherence tomography (AS-OCT) and in vivo confocal microscopy (IVCM). Materials and Methods: Twenty-eight eyes of 28 patients who underwent glaucoma filtering surgery with mitomycin C in our clinic between 2009 and 2013 were evaluated. Morphological appearances of the blebs on slit-lamp biomicroscopy were defined according to the Moorfields bleb classification system. For the internal tissue assessment of blebs, AS-OCT and IVCM were performed. Bleb biometric parameters such as length, height and bleb wall thickness were assessed by AS-OCT; conjunctival epithelial-stromal cyst, structural network of conjunctival stroma and vascularisation were examined with IVCM. The relation between biomicroscopic morphological staging and bleb characteristics detected on AS-OCT and IVCM were assessed. Results: The mean age of the 28 patients (16 male, 12 female) was 57.2±15.9 (19 to 79) years. The mean time elapsed between surgery and examination was 29.2±19.2 (6 to 68) months. According to biomicroscopic appearance, 17 (60.7%) blebs were functional (13 diffuse, 4 microcystic), whereas 11 (39.3%) blebs were non-functional (9 flat, 2 encapsulated). In the comparison of non-functional and functional blebs, functional blebs were found to be superior in terms of biometric parameters on AS-OCT assessment (p<0.05). Higher number of epithelial and stromal cysts and less vascularisation were detected by IVCM in functional blebs when compared with non-functional blebs (p<0.05). Conclusion: Biomicroscopic appearances and characteristics on AS-OCT and IVCM of filtration blebs are consistent with each other. Besides biomicroscopic examination, which is an easy and practical method for determining bleb morphology, cross-sectional images obtained by AS-OCT and IVCM provide objective data regarding internal structure and functional features of blebs. © 2015, Turkish Ophthalmology Society. All rights reserved.en_US
dc.identifier.doi10.4274/tjo.29052
dc.identifier.endpage137en_US
dc.identifier.issn1300-0659
dc.identifier.issn1300-0659en_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage132en_US
dc.identifier.urihttps://doi.org/10.4274/tjo.29052
dc.identifier.urihttps://hdl.handle.net/11454/17133
dc.identifier.volume45en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTurkish Ophthalmology Societyen_US
dc.relation.ispartofTurk Oftalmoloiji Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnterior segment optical coherence tomographyen_US
dc.subjectBiomicroscopyen_US
dc.subjectBleben_US
dc.subjectIn vivo confocal microscopyen_US
dc.titleEvaluation of filtering bleb function after trabeculectomy with mitomycin C using biomicroscopy, anterior segment optical coherence tomography and in vivo confocal microscopyen_US
dc.typeArticleen_US

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