Bioevaluation of 99mTc(I) carbonyl-radiolabeled amino acid coated magnetic nanoparticles in vivo
Küçük Resim Yok
Tarih
2019
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this paper, amino acid coated and radiolabeled magnetic nanoparticles (MNPs) were prepared as a potential diagnostic agent. Magnetic nanoparticles were synthesized and functionalized by L-alanine and L-cysteine amino acids in one step. Besides surface functionalization, amino acid coating also provided favourable particle size. Structural characterization was performed by scanning electron microscopy. We obtained 30–38 nm and 22–30 nm diameter ranges with spherical shape for L-alanine and L-cysteine coated nanoparticles, separately. Then L-alanine and L-cysteine coated MNPs were radiolabeled with 99mTc(I)-tricarbonyl core (99mTc(CO)3-Alanine-MNP, 99mTc(CO)3-Cysteine-MNP) with a labeling yield of 63 ± 3% and 74 ± 2%. Pure radiolabeled magnetic particles were obtained by washing them with saline solution, and the radiochemical purity of 99mTc(CO)3-Alanine-MNP and 99mTc(CO)3-Cysteine-MNP were found as 94.3 ± 0.47% and 97.6 ± 1.06% in each of the final solution, respectively. In addition, both radiolabeled nanoparticles were stabile up to 4 h at 37 °C temperature in vitro conditions. After radiolabeling with 99m-Technetium tricarbonyl core, biological behaviour of nanoparticles was evaluated for each in vivo on male Wistar Albino rats. © 2019 Elsevier B.V.
Açıklama
Anahtar Kelimeler
99m-technetium tricarbonyl core, In vivo, Magnetic nanoparticles, Radiolabeling
Kaynak
Materials Chemistry and Physics
WoS Q Değeri
Scopus Q Değeri
Q1
Cilt
235
