Simultaneous quantitative analysis of biologically important Amaryllidaceae alkaloids in Narcissus tazetta L. subsp. tazetta by HPLC/PDA

Basit Öğe Kaydı
dc.contributor.authorKarakoyun, Cigdem
dc.contributor.authorUnver-Somer, Nehir
dc.date.accessioned2019-10-27T09:48:10Z
dc.date.available2019-10-27T09:48:10Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.description.abstractThe present study was conducted for the quantitative determination of biologically active Amaryllidaceae alkaloids, galanthamine and lycorine, in the bulbs and aerial parts of a subspecies naturally growing in Turkey namely, Narcissus tazetta L. subsp. tazetta collected from Mugla/Turkey. A reverse phase high performance liquid chromatographic method using an isocratic system consisting of trifluoroacetic acid:water:acetonitrile (0.01:90:10) with a flow rate of 1 mL/min was carried out. Photodiode array detection was employed to determine the UV-visible spectral characteristics of the alkaloids. Determination of acetylcholinesterase and butyrylcholinesterase inhibitory activities of different parts of mentioned subspecies were accomplished using a microplate assay modified from Ellman's method. This is the first report of the galanthamine content of Narcissus tazetta subsp. tazetta of Turkish origin. 0.0051% and 0.0055% galanthamine was detected in the bulbs and aerial parts of the plant, respectively. Also, lycorine was determined as 0.0250% in the bulbs and 0.0672 % in the aerial parts.en_US
dc.identifier.doi10.12991/jrp.2019.156
dc.identifier.endpage505en_US
dc.identifier.issn2630-6344
dc.identifier.issn2630-6344en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage498en_US
dc.identifier.urihttps://doi.org/10.12991/jrp.2019.156
dc.identifier.urihttps://hdl.handle.net/11454/29491
dc.identifier.volume23en_US
dc.identifier.wosWOS:000468157000015en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMarmara Univen_US
dc.relation.ispartofJournal of Research in Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAmaryllidaceaeen_US
dc.subjectalkaloiden_US
dc.subjectgalanthamineen_US
dc.subjectlycorineen_US
dc.subjectquantitative determinationen_US
dc.titleSimultaneous quantitative analysis of biologically important Amaryllidaceae alkaloids in Narcissus tazetta L. subsp. tazetta by HPLC/PDAen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu