The Effects of Melatonin on Transcriptional Profile of Unfolded Protein Response Genes Under Endoplasmic Reticulum Stress in Arabidopsis thaliana

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dc.contributor.authorOzgur, Rengin
dc.contributor.authorUzilday, Baris
dc.contributor.authorTurkan, Ismail
dc.contributor.authorSekmen, A. Hediye
dc.date.accessioned2019-10-27T11:09:34Z
dc.date.available2019-10-27T11:09:34Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractWhen the load of secretory pathway is increased or folding capacity in the endoplasmic reticulum (ER) is insufficient, unfolded proteins might accumulate in ER lumen causing a phenomenon called ER stress. During ER stress, normal cell functions are suppressed and unfolded protein response (UPR) is induced. Studies in animal systems suggest that melatonin alleviates the detrimental effects of ER stress; however, there is no study in plants in this respect. Hence, in this study, we investigated the possible role of melatonin on alleviation of ER stress in model plant Arabidopsis thaliana. Tunicamycin (Tm) was used to specifically induce ER stress. Melatonin treatment (10 and 25 mu M but not 1 mu M) increased root growth under Tm treatment, but it did not reach control levels. ER stress induced the expressions of ER stress sensor/transducer genes, ER chaperones and folding helper genes, ER-associated degradation (ERAD) genes, and ER stress-associated apoptosis genes in roots and shoots (a total of 16 genes). Among them, the expressions of ER stress sensor/transducer bZIP17, bZIP28, IRE1A, IRE1B, ERAD-related SEL1, and apoptosis genes AGB1 were decreased back to control levels with 25 mu M melatonin under ER stress in roots. Moreover, Tm + melatonin treatments decreased the expressions of these genes when compared to only Tm-treated plants. Downregulation of UPR components with increased concentrations of melatonin under Tm treatment demonstrated that melatonin alleviated the detrimental effects of ER stress.en_US
dc.identifier.doi10.1007/s11105-016-1015-x
dc.identifier.endpage202en_US
dc.identifier.issn0735-9640
dc.identifier.issn1572-9818
dc.identifier.issn0735-9640en_US
dc.identifier.issn1572-9818en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage188en_US
dc.identifier.urihttps://doi.org/10.1007/s11105-016-1015-x
dc.identifier.urihttps://hdl.handle.net/11454/32301
dc.identifier.volume35en_US
dc.identifier.wosWOS:000396590000002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPlant Molecular Biology Reporteren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectArabidopsisen_US
dc.subjectER stressen_US
dc.subjectER-associated degradationen_US
dc.subjectERADen_US
dc.subjectMelatoninen_US
dc.subjectUnfolded protein responseen_US
dc.subjectUPRen_US
dc.titleThe Effects of Melatonin on Transcriptional Profile of Unfolded Protein Response Genes Under Endoplasmic Reticulum Stress in Arabidopsis thalianaen_US
dc.typeArticleen_US

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