Necrotising Fasciitis: Clinical Evaluation and Treatment Results of 18 Patients

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dc.contributor.authorOzturk, Anil Murat
dc.contributor.authorAkyol, Deniz
dc.contributor.authorSuer, Onur
dc.contributor.authorErdem, Huseyin Aytac
dc.contributor.authorSimsir, Ilgin Yildirim
dc.contributor.authorAkar, Sebnem Senol
dc.contributor.authorTasbakan, Meltem Isikgoz
dc.date.accessioned2020-12-01T12:09:50Z
dc.date.available2020-12-01T12:09:50Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.description.abstractIntroduction: Necrotizing fasciitis (NF) is a complicated and rapidly spreading soft tissue infection that affects the superficial fascia, skin, and subcutaneous tissue. in this study, we evaluated patients who were diagnosed with NF and treated in two tertiary-care educational university hospitals. Materials and Methods: Patients diagnosed with NF in three centers (Ege University Department of Orthopedics and Traumatology and Department of Infectious Diseases and Clinical Microbiology and Celal Bayar University Department of Infectious Diseases and Clinical Microbiology) between November 2016 and December 2018 were retrospectively analyzed. the patients' demographic characteristics, significant risk factors for infection, sites of infection, models of surgical treatment, department(s) that performed the surgery, causative infectious agents, empirical and agent-specific treatment regimens and their duration, length of hospital stay, need for intensive care, and one month survival were evaluated. Results: Eighteen patients (10 females, mean age 53.7 [19-86 years]) who were diagnosed with NF were included in the study. Diabetes mellitus, trauma/surgery history, and decubitus wound were the most common predisposing factors. the most common anatomic site was lower extremity (n=10, 55.5%). All patients underwent surgical debridement. the most commonly isolated microorganisms were Escherichio coli (n=4), Klebsiella pneumoniae, Proteus mirabilis, and Acinetobacter boumannii (each n=3). Empirical treatment was initiated with meropenem in eight patients (32%) and tigecycline in four patients (12.5%), and the antibiotic was changed in five patients based on culture results. the mean duration of antibiotic therapy was 35.5 (9-68) days. the average hospital stay was 55 (11-186) days. Six patients (33.3%) required intensive care during follow-up. the mortality rate was 16.6%. Conclusion: NF is a fulminant disease, and early diagnosis and effective multidisciplinary treatment are crucial for reducing mortality rates. When the diagnosis is suspected, early surgical debridement should be performed and empirical antibiotherapy should be started immediately.en_US
dc.identifier.doi10.4274/mjima.galenos.2019.2019.9
dc.identifier.issn2147-673X
dc.identifier.issn2147-673Xen_US
dc.identifier.urihttps://doi.org/10.4274/mjima.galenos.2019.2019.9
dc.identifier.urihttps://hdl.handle.net/11454/63585
dc.identifier.volume8en_US
dc.identifier.wosWOS:000511368300009en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofMediterranean Journal of Infection Microbes and Antimicrobialsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMultidisciplinary approachen_US
dc.subjectcomplicated skin and soft tissue infectionen_US
dc.subjectlinezoliden_US
dc.subject'Laboratory Risk Indicator for Necrotizing Fasciitis' (LRINEC) scoreen_US
dc.subjectertapenemen_US
dc.titleNecrotising Fasciitis: Clinical Evaluation and Treatment Results of 18 Patientsen_US
dc.typeArticleen_US

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