Clinical outcome of pcr-negative covid-19 patients: A retrospective study
Küçük Resim Yok
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
AVES
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
OBJECTIVE: To evaluate the clinical features and outcomes of patients who were admitted with a diagnosis of coronavirus disease 2019 (COVID-19) but who were not confirmed with polymerase chain reaction (PCR) positivity. MATERIAL AND METHODS: This is a retrospective analysis of all patients admitted to two tertiary care centers between March 15 and May 15, 2020, with a diagnosis of COVID-19. From a common database prepared for COVID-19, we retrieved the relevant data and compared the clinical findings and outcomes of PCR-positive patients with those of PCR-negative cases who had been diagnosed on the basis of typical clinical and radiographic findings. RESULTS: A total of 349 patients were included in the analysis, of which 126 (36.1%) were PCR-negative. PCR-negative patients were younger (54.6 ± 20.8 vs. 60.8 ± 18.9 years, P = .009) but were similar to PCR-positive patients in terms of demographics, comorbidities, and presenting symptoms. They had higher lymphocyte counts (1519 ± 868 vs. 1331 ± 737/mm3, P = .02) and less frequently presented with bilateral radiographic findings (68.3% vs. 79.4%, P = .046) than PCR-positive patients. Besides, they had less severe disease and better clinical outcomes regarding admission to the intensive care unit (9.6% vs. 20.6%, P = .023), oxygen therapy (21.4% vs. 43.5%, P < .001), ventilatory support (3.2% vs. 11.2%, P = .03) and length of hospital stay (5.0 ± 5.0 vs. 9.7 ± 5.9 days, P < .001). CONCLUSION: This study confirms that about one-third of the COVID-19 patients are PCR-negative and diagnosed based on clinicaand radiographic findings. These patients have a more favorable clinical course, shorter hospital stays, and are less frequently admitteto the intensive care unit. © 2021 by Turkish Thoracic Society.
Açıklama
Anahtar Kelimeler
COVID-19, Diagnosis, Outcome, Polymerase chain reaction, alanine aminotransferase, aspartate aminotransferase, C reactive protein, creatinine, D dimer, favipiravir, ferritin, glucocorticoid, hydroxychloroquine, lactate dehydrogenase, procalcitonin, tocilizumab, anticoagulant therapy, antiinflammatory activity, Article, artificial ventilation, blood gas analysis, clinical feature, clinical outcome, computer assisted tomography, coronavirus disease 2019, fraction of inspired oxygen, hospital mortality, human, intensive care unit, invasive ventilation, length of stay, lymphocyte count, major clinical study, nasopharyngeal swab, noninvasive ventilation, oxygen saturation, oxygen therapy, pneumonia, polymerase chain reaction, pulse oximetry, radiography, retrospective study, reverse transcription polymerase chain reaction, Severe acute respiratory syndrome coronavirus 2, supportive care need, thorax radiography
Kaynak
Turkish Thoracic Journal
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
22
Sayı
3
