Investigation of new bifunctional agents: D-Penicillamine

Basit Öğe Kaydı
dc.contributor.authorAcar, C.
dc.contributor.authorTeksoez, S.
dc.contributor.authorUenak, P.
dc.contributor.authorBiber, F. Z.
dc.date.accessioned2019-10-27T19:32:46Z
dc.date.available2019-10-27T19:32:46Z
dc.date.issued2007
dc.departmentEge Üniversitesien_US
dc.description.abstractSomatostatin inhibits the release of growth hormone (somatotropin) from the Anterior Pituitary. The main use of derivatives of somatostatin is to diagnose growth hormone problems and to use against some forms of cancer which involve growth hormone. Also somatostatin suppresses gastric acid secretion, gallbladder contractions, and pancreatic enzyme secretion. The aim of the current study is to investigate new bifunctional agents for labeling with Tc-99m. Therefore D-Penicillamine was used as a bifunctional agent and compared to DTPA in the labeling with(99m)Tc. Quality controls were established using thin layer radio chromatography (TLRC) and electrophoresis techniques. In addition, high performance liquid radio chromatography (HPLRC) was also performed for elimination of possible uncertainties. The radiolabeled complexes maintained their stabilities throughout the study. The results obtained showed that Tc-99m-D-Penicillamine-somatostatin is a promising potential radiopharm aceutical and an alternative of Tc-99m-DTPA-somatostatin for in vivo and in vitro applications.en_US
dc.identifier.doi10.1007/s10967-007-0924-4
dc.identifier.endpage647en_US
dc.identifier.issn0236-5731
dc.identifier.issn1588-2780
dc.identifier.issn0236-5731en_US
dc.identifier.issn1588-2780en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage641en_US
dc.identifier.urihttps://doi.org/10.1007/s10967-007-0924-4
dc.identifier.urihttps://hdl.handle.net/11454/39354
dc.identifier.volume273en_US
dc.identifier.wosWOS:000248612300024en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Radioanalytical and Nuclear Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleInvestigation of new bifunctional agents: D-Penicillamineen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu