Optimizing subcritical water extraction of Morus nigra L. fruits for maximization of tyrosinase inhibitory activity

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dc.contributor.authorKoyu, Halil
dc.contributor.authorKazan, Aslihan
dc.contributor.authorOzturk, Taylan Kurtulus
dc.contributor.authorYesil-Celiktas, Ozlem
dc.contributor.authorHaznedaroglu, Mehmet Zeki
dc.date.accessioned2019-10-27T11:06:21Z
dc.date.available2019-10-27T11:06:21Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractThe process of preparing extracts for pharmaceutical industry from natural resources is a challenge to obtain effective constituents besides using resources efficiently considering public health and environment. Advanced extraction technologies aim to provide high efficiency and selectivity apart from decreasing the demand for organic solvents causing toxic residuals. In line with this objective, optimization of subcritical water extraction of Morus nigra L. fruits had been carried out with response surface methodology. Bioactive constituents as phenolics, flavonoids and anthocyanins were determined with spectrophotometry and LC MS/MS analysis. Optimum extraction conditions were elicited as 60 degrees C, 60 min, 2 ml/min yielding an IC50 value of 1.84 mg/ml and subcritical conditions at 120 degrees C, 60 min, 2ml/min yielding 1.71 mg/ml which possess stronger activity than extracts of conventional solvent extraction (2.81 mg/ml) regarding tyrosinase inhibitory activity. Consequently, subcritical water could be a pioneer for green extraction systems for Moms nigra L. fruits compared to conventional solvent extraction. (C) 2017 Published by Elsevier B.V.en_US
dc.description.sponsorshipScientific and Technical Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [2165839]; Council of Higher Educationen_US
dc.description.sponsorshipAccesses to the facilities of Novel Fluidic Technologies Laboratory at Department of Bioengineering and Pharmaceutical Sciences Research Center (FABAL) are highly appreciated. This study was supported by the Scientific and Technical Research Council of Turkey (TUBITAK) through 2165839 project and OYP fund supplied by The Council of Higher Education (YOK).en_US
dc.identifier.doi10.1016/j.supflu.2017.03.007
dc.identifier.endpage22en_US
dc.identifier.issn0896-8446
dc.identifier.issn1872-8162
dc.identifier.issn0896-8446en_US
dc.identifier.issn1872-8162en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage15en_US
dc.identifier.urihttps://doi.org/10.1016/j.supflu.2017.03.007
dc.identifier.urihttps://hdl.handle.net/11454/31841
dc.identifier.volume127en_US
dc.identifier.wosWOS:000405879400003en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofJournal of Supercritical Fluidsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMoms nigraen_US
dc.subjectSubcritical wateren_US
dc.subjectExtractionen_US
dc.subjectLC-MS/MSen_US
dc.subjectTyrosinase inhibitionen_US
dc.titleOptimizing subcritical water extraction of Morus nigra L. fruits for maximization of tyrosinase inhibitory activityen_US
dc.typeArticleen_US

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