Dosimetric Comparison of Volumetric and Intensity-modulated Radiotherapy Techniques in Cervical Cancer Patients with Paraaortic Lymph Node Metastasis

Basit Öğe Kaydı
dc.contributor.authorEnet, Irem Alemdar
dc.contributor.authorEren, Hakan
dc.contributor.authorOlacak, Nezahat
dc.contributor.authorOzsaran, Zeynep
dc.date.accessioned2024-08-31T07:47:31Z
dc.date.available2024-08-31T07:47:31Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractOBJECTIVE To compare the dosimetric criteria of intensity-modulated radiotherapy (IMRT) and volumetric modulated radiotherapy (VMAT) plans with simultaneous integrated boost (SIB) technique in cervical cancer patients with para-aortic lymph node (PALN) metastases. METHODS SIB-IMRT and SIB-VMAT plans of 10 patients were retrospectively analyzed. The elective volume received 45 Gy(PTV45) in 25 fractions of 1.8 Gy, while the integrated boost volume (lymph nodes) simultaneously received 55 Gy (PTV55). Using the same dose constraints in optimization, IMRT plans consisted of 9 fields, while VMAT plans were performed with 2 full arcs. Volume and dose parameters were determined across the planning target volume, bladder, bowel, femoral heads, kidneys, liver, rectum, sigmoid, and spinal cord. Conformity and homogeneity indices were calculated, the Monitor Unit (MU) was analyzed, and the Wilcoxon-signed rank test was applied for statistical analysis (p <= 0.05). RESULTS Both techniques were found to be effective for treatment, but there was a significant difference in favor of SIB-VMAT in terms of target volume reaching the predicted dose and protection of critical organs (OAR) (p=0.028). For PTV55, MU and right-left kidney; V-20,V-30- V-20, V-30, liver; D-ort , liver values were significantly different (p=0.005, p=0.005, p=0.005, p=0.02, p=0.005, p=0.007, p=0.03, respectively). In SIB-IMRT, a significant difference was observed for CI value close to 1 (p=0.02). CONCLUSION The SIB-VMAT technique showed lower MU, kidney, and liver values, and SIB-IMRT showed better CI values. Other parameters indicated that the two planning techniques were nearly equivalent. These findings indicate the different efficacies of treatment techniques in radiotherapy planning for cervical cancer patients who were diagnosed with PALN metastases.en_US
dc.identifier.doi10.5505/tjo.2024.4336
dc.identifier.issn1300-7467
dc.identifier.urihttps://doi.org/10.5505/tjo.2024.4336
dc.identifier.urihttps://hdl.handle.net/11454/104457
dc.identifier.wosWOS:001271310400001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherKare Publen_US
dc.relation.ispartofTurk Onkoloji Dergisi-Turkish Journal of Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240831_Uen_US
dc.subjectCanceren_US
dc.subjectCervicalen_US
dc.subjectIntensity-Modulated Radiotherapy (Imrt)en_US
dc.subjectMetastasisen_US
dc.subjectPara-Aortic Lymph Node (Paln)en_US
dc.subjectVolumetric Modulated Radiotherapy (Vmat)en_US
dc.titleDosimetric Comparison of Volumetric and Intensity-modulated Radiotherapy Techniques in Cervical Cancer Patients with Paraaortic Lymph Node Metastasisen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu